PRENATAL AND POSTNATAL GROWTH AND DEVELOPMENT OF CENTRAL NERVOUS SYSTEM OF PIG
PRENATAL AND POSTNATAL GROWTH AND DEVELOPMENT OF CENTRAL NERVOUS SYSTEM OF PIG
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DOI：
10.1098/rspb.1967.0002
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发表时间：
1967-01-01
期刊：
影响因子：
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通讯作者：
DOBBING, J
中科院分区：
文献类型：
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作者：
DICKERSON, JW;DOBBING, J
本实验研究了猪从妊娠第52天到3岁的脑和脊髓的生长和化学发育。年龄。大脑的重量比脊髓增加得快。其生长最快的时期从出生前约50天持续到出生后约40天，并由以DNA-P沉积为特征的早期和以脂质沉积为特征的晚期组成。在发育过程中，中枢神经系统各部分含水量的百分比下降，总氮、磷脂-P和胆固醇的浓度上升。在整个研究期间，大脑中DNA-P的浓度逐渐下降，但在小脑和脑干中，下降之前，在妊娠95天左右达到峰值浓度。小脑是中枢神经系统中唯一一个DNA-P绝对量在2岁以前达到成熟值的部位。脊髓没有早期生长突增，因此，胆固醇和磷脂-P的绝对量没有明显迅速上升的时间。有一个时期，胆固醇浓度增加最快，这与中枢神经系统其他部位的胆固醇浓度增加最快相一致。这些结果的影响，应力对中枢神经系统的roadhemont的轴承进行了讨论。
The growth and chemical development of the brain and spinal cord of the pig were studied between the 52nd day of gestation and 3 yr. of age. The brain increased in weight faster than the spinal cord. Its most rapid period of growth lasted from about 50 days before birth to about 40 days afterwards and was made up of an early period characterized by DNA-P deposition and a later one of lipid deposition. The percentage of water in each part of the central nervous system fell during development and the concentrations of total N, phospholipid-P and cholesterol rose. The concentration of DNA-P fell gradually over the period studied in the brain as a whole, but in the cerebellum and brain stem the fall was preceded by a rise to a peak concentration at about 95 days of gestation. The cerebellum was the only part of the central nervous system examined in which the absolute amount of DNA-P attained a mature value before 2 years of age. The spinal cord had no early growth spurt and for this reason there was no time when the absolute amounts of cholesterol and phospholipid-P were rising conspicuously rapidly. There was, a period when the concentration of cholesterol increased most rapidly and this coincided with the 1 in other parts of the central nervous svstem. The bearing of these results on the effects of stress on the rovelopmont of the central nervous system is discussed.