Tracking of clustered cardiovascular disease risk factors from childhood to adolescence
Tracking of clustered cardiovascular disease risk factors from childhood to adolescence
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DOI：
10.1038/pr.2012.158
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发表时间：
2013-02-01
影响因子：
3.6
通讯作者：
Andersen, Lars Bo
中科院分区：
文献类型：
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作者：
Bugge, Anna;El-Naaman, Bianca;Andersen, Lars Bo
背景：心血管疾病（CVD）危险因素的聚集性在9岁的儿童中就已发现。然而，这种集群在整个童年时期的稳定性尚未确定。本研究的目的是确定从年轻的学龄期到青春期的聚集性CVD风险的跟踪，并检查超重/肥胖和心肺功能（VO 2 peak）水平之间的跟踪差异。方法：从6岁开始，儿童（n = 434）在7岁时进行了三次测量。测量人体测量学、血压和VO 2峰值。分析空腹血液样本的CVD风险因素。通过增加血压、稳态模型评估（HOMA-IR）、甘油三酯（TG）、皮褶厚度、高密度脂蛋白胆固醇（HDLc）和VO 2峰值的负值的性别特异性z分数，构建了聚集风险分数（z分数）。在所有时间间隔的聚类z分数之间发现了显著的跟踪系数（6-9岁、9-13岁和6-13岁之间的r分别为0.514、0.559和0.381，均P < 0.0001）。跟踪低适合的儿童，而没有明确的模式，发现不同水平的体脂。结论：我们发现，集群Z-分数是一个相当稳定的特点，通过童年。因此，预防战略的实施可以从学龄早期开始。
BACKGROUND: Clustering of cardiovascular disease (CVD) risk factors has been found in children as young as 9 y of age. However, the stability of this clustering over the course of childhood has yet to be determined. The purpose of this study was to determine the tracking of clustered CVD risk from young school age through adolescence and to examine differences in tracking between levels of overweight/obesity and cardiorespiratory fitness (VO2peak).METHODS: Beginning at 6 y, children (n = 434) were measured three times in 7 y. Anthropometrics, blood pressure, and VO2peak were measured. Fasting blood samples were analyzed for CVD risk factors. A clustered risk score (z-score) was constructed by adding sex-specific z-scores for blood pressure, homeostatic model assessment (HOMA-IR), triglyceride (TG), skinfolds, and negative values of high-density lipoprotein cholesterol (HDLc) and VO2peak.RESULTS: Significant tracking coefficients were found between clustered z-score at all time intervals (r=0.514, 0.559, and 0.381 between ages 6-9, 9-13, and 6-13 y, respectively, all P < 0.0001). Tracking was higher for low-fit children, whereas no clear pattern was found for different levels of body fat.CONCLUSION: We found that clustered z-score is a fairly stable characteristic through childhood. Implementation of preventive strategies could therefore start at early school age.