The role of MIP-1 alpha in inflammation and hematopoiesis
The role of MIP-1 alpha in inflammation and hematopoiesis
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DOI：
10.1002/jlb.59.1.61
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发表时间：
1996-01-01
影响因子：
5.5
通讯作者：
Cook, DN
中科院分区：
文献类型：
--
作者：
Cook, DN
巨噬细胞炎症蛋白1 α（MIP-1 α）是趋化因子的C-C亚家族的成员，所述趋化因子是在体外表现出多种促炎活性（包括白细胞趋化性）的低分子量、可诱导蛋白质的大超家族。MIP-1 α是特别令人感兴趣的趋化因子，因为除了其促炎活性之外，它在体外和体内抑制造血干细胞的增殖，在这里，生物：MIP-1 α的特性是根据最近的数据对小鼠的MIP-1 α基因的破坏纯合子。MIP-1 α缺失小鼠的外周血或骨髓细胞没有明显的异常，表明MIP-1 α对于正常的造血不是必需的。然而，MIP-1 α缺失小鼠对流感病毒的炎症反应降低，并且对柯萨奇病毒诱导的心肌炎具有抗性。这些数据表明，MIP-1 α是对这些病毒的正常炎症反应所必需的。因此，抑制MIP-1 α作用的药物可能被证明可用于控制这些和其他环境中的炎症。
Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a member of the C-C subfamily of chemokines, a large superfamily of low-molecular-weight, inducible proteins that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis, MIP-1 alpha is a particularly interesting chemokine, because in addition to its proinflammatory activities, it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo, Here, the biologic: properties of MIP-1 alpha are reviewed in light of recent data on mice homozygous for a disruption of the MIP-1 alpha gene. The MIP-1 alpha null mice have no overt abnormalities of peripheral blood or bone marrow cells, indicating that MIP-1 alpha is not necessary for normal hematopoiesis. However, the MIP-1 alpha null mice have a reduced inflammatory response to influenza virus and are resistant to coxsackievirus-induced myocarditis, These data demonstrate that MIP-1 alpha is required for a normal inflammatory response to these viruses. Agents that inhibit the action of MIP-1 alpha may therefore prove useful for controlling inflammation in these and other settings.