On an epidemic of acute glomerulonephritis in Amsterdam.
On an epidemic of acute glomerulonephritis in Amsterdam.
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关于阿姆斯特丹急性肾小球肾炎的流行。
DOI：
10.1111/j.0954-6820.1948.tb09322.x
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发表时间：
2009
影响因子：
--
通讯作者：
P. Formijne
中科院分区：
文献类型：
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作者：
P. Formijne
关于急性肾小球肾炎的病因学一直存在着不同的观点和理论。这种疾病的名字表明以前的感染性病原学已被假定。但在大多数急性肾小球肾炎病例中，缺乏急性感染的典型体征。很少有柔情。通常不会发烧。在尿液中没有发现细菌。在许多情况下，身体其他部位的感染和急性肾炎之间的关系是特殊的。在这些病例中，通常可以看到肾炎在感染开始后的一段相当长的时间内开始，例如心绞痛、中耳炎、皮肤感染等。最初的感染通常在肾炎开始时消退。在猩红热中，肾炎通常在发病后2至3周开始。急性肾炎临床表现的这些特点导致了一种理论，即没有真正的感染，但肾炎是由过敏机制引起的。这一理论通过Masugi(1)的实验得到了坚实的基础，他能够通过抗原-抗体反应引起典型的肾炎。将大鼠肾悬液注入兔体内，引起兔血清中出现抗大鼠肾抗体。当该兔免疫血清注射到另一只大鼠体内时，肾炎也随之发生。通过这种方式，可以证明与过敏现象密切相关的一种机制会导致肾炎。
The etiology of acute glomerulonephritis had been the subject of different opinions and theories. The name of this disease in-dicates that formerly an infective etiology has been assumed. But in most cases of acute glomerulonephritis the typical signs of acute infection are absent. There is seldom tenderness. Fever is often absent. No bacteria are found in the urine. In many cases the relations between infection elsewhere in the body and acute nephritis is peculiar. In those cases it is often seen that the nephritis starts some considerable time after the beginning of the infection, for instance an angina, otitis, skin-infection etc. The original infection has often subsided at the time of the beginning of the nephritis. In scarlet fever the nephritis mostly starts from 2 to 3 weeks after the beginning of the disease. These pecularities in the clinical picture of the acute nephritis have led to the theory that there is no real infection, but that the nephritis is caused by allergic mechanism. This theory has got a solid foundation through the experiments of Masugi (1) who was able to cause a typical nephritis by an antigen-antibody reaction. A suspension of rat-kidney was injected into rabbits and caused the appearance of antibodies against rat-kidne y in the serum of this rabbit. When this immune-serum of the rabbit was injected into another rat nephritis followed. In this manner it could be demonstrated that a mechanism closely related to allergic phenomena would cause nephritis.