COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence.
COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence.
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DOI：
10.1155/2010/678648
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发表时间：
2010
影响因子：
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通讯作者：
Hnrc Group T
中科院分区：
文献类型：
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作者：
Bousman CA;Cherner M;Atkinson JH;Heaton RK;Grant I;Everall IP;Hnrc Group T
儿茶酚-O-甲基转移酶 (COMT) 代谢前额皮质多巴胺 (DA)，这是一种参与执行行为的神经递质； Val158Met 基因型与执行功能障碍有关，这可能会增加有利于艾滋病毒传播的性危险行为。研究了 COMT 基因型和执行功能对危险性行为的主要影响和交互影响。 192 名性活跃的非一夫一妻制男性完成了性行为问卷、执行功能测试，并使用血液 DNA 进行了基因分型。观察到执行功能障碍对性伴侣数量的主要影响，但 COMT 没有。在性伴侣数量和插入性肛交中发现了 COMT x 执行功能障碍的相互作用，这对于 Met/Met 携带者以及较小程度上的 Val/Met 基因型携带者而言很重要，但对于 Val/Val 携带者则不显着。在 HIV 和甲基苯丙胺依赖的情况下，Met/Met 基因型赋予的前额皮质多巴胺能过度活跃似乎会导致执行功能障碍和潜在相关的危险性行为。
Catechol-O-methyltransferease (COMT) metabolizes prefrontal cortex dopamine (DA), a neurotransmitter involved in executive behavior; the Val158Met genotype has been linked to executive dysfunction, which might increase sexual risk behaviors favoring HIV transmission. Main and interaction effects of COMT genotype and executive functioning on sexual risk behavior were examined. 192 sexually active nonmonogamous men completed a sexual behavior questionnaire, executive functioning tests, and were genotyped using blood-derived DNA. Main effects for executive dysfunction but not COMT on number of sexual partners were observed. A COMT x executive dysfunction interaction was found for number of sexual partners and insertive anal sex, significant for carriers of the Met/Met and to a lesser extent Val/Met genotypes but not Val/Val carriers. In the context of HIV and methamphetamine dependence, dopaminergic overactivity in prefrontal cortex conferred by the Met/Met genotype appears to result in a liability for executive dysfunction and potentially associated risky sexual behavior.