Microstructural changes in the spinal cord of adults with cerebral palsy.
Microstructural changes in the spinal cord of adults with cerebral palsy.
复制标题
脑瘫成年人的脊髓的微观结构变化。
DOI：
10.1111/dmcn.14860
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发表时间：
2021-08
影响因子：
3.8
通讯作者：
Kurz MJ
中科院分区：
文献类型：
--
作者：
Trevarrow MP;Baker SE;Wilson TW;Kurz MJ
目的：量化脑性瘫痪（CP）成人颈胸段脊髓的显微结构差异。对一组成年CP患者进行近端脊髓（C6-T3）的磁共振成像（n=13;平均年龄= 31岁11个月，标准差[SD] 8岁7个月;范围= 20岁8个月-47岁6个月; 8名女性，5名男性）和群体正常成人对照（n=16;平均年龄= 31岁4个月，SD 9岁9个月;范围= 19岁4个月-49岁5个月; 7名女性，9名男性）。计算脊髓、灰质和白色物质的横截面积（CSA）、楔束和皮质脊髓束的磁化传递比（MTR）和各向异性分数。成年CP患者脊髓横截面积和脊髓灰质横截面积比例明显降低。成年CP患者皮质脊髓束MTR较正常人低。灰质减少的个体也倾向于皮质脊髓束的MTR减少（r=0.42，p=0.029）和手灵活性临床评分更差（r=0.53，p=0.004）。这些结果表明，有改变的脊髓显微结构的成年人与CP。最终，这些微结构的变化发挥了作用的程度手感觉运动缺陷的成年人与CP。
To quantify the microstructural differences in the cervical-thoracic spinal cord of adults with cerebral palsy (CP). Magnetic resonance imaging of the proximal spinal cord (C6–T3) was conducted on a cohort of adults with CP (n=13; mean age=31y 11mo, standard deviation [SD] 8y 7mo; range=20y 8mo–47y 6mo; eight females, five males) and population norm adult controls (n=16; mean age=31y 4mo, SD 9y 9mo; range=19y 4mo–49y 5mo; seven females, nine males). The cross-sectional area (CSA) of the spinal cord, gray and white matter, magnetization transfer ratio (MTR), and fractional anisotropy of the cuneatus and corticospinal tracts were calculated. The total spinal cord CSA and proportion of the spinal cord gray matter CSA were significantly decreased in the adults with CP. The corticospinal tracts’ MTR was lower in the adults with CP. Individuals that had reduced gray matter also tended to have reduced MTR in their corticospinal tracts (r=0.42, p=0.029) and worse hand dexterity clinical scores (r=0.53, p=0.004). These results show that there are changes in the spinal cord microstructure of adults with CP. Ultimately, these microstructural changes play a role in the extent of the hand sensorimotor deficits seen in adults with CP.
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