A genome-wide association study for reading and language abilities in two population cohorts.
A genome-wide association study for reading and language abilities in two population cohorts.
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DOI：
10.1111/gbb.12053
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Bates TC
中科院分区：
文献类型：
--
作者：
Luciano M;Evans DM;Hansell NK;Medland SE;Montgomery GW;Martin NG;Wright MJ;Bates TC
阅读和语言的候选基因已经被确定，但这些性状的大多数遗传变异仍然无法解释。在这里，我们报告了两个大型队列的全基因组关联荟萃分析：12-25岁的澳大利亚双胞胎和兄弟姐妹的人口样本（来自538个家庭的n = 1177人），以及英国雅芳父母及其子女纵向研究的年轻儿童队列（8岁和9岁；最大n = 5472人）。阅读测量和非单词重复（NWR）之间存在暗示性关联，假基因 ABCC13（P = 7.34 × 10−8）和基因 DAZAP1（P = 1.32 × 10−6）中的单核苷酸多态性（SNP）得到了最大的支持。基于基因的分析显示，阅读和拼写与 1 号染色体上两个基因座的 CD2L1、CDC2L2 和 RCAN3 基因存在显着关联 (P < 2.8 × 10−6)。我们发现了一些支持对阅读技能和 NWR 都有影响的相同 SNP，这与阅读习得对语音任务表现影响的行为遗传学证据相一致。结果表明，新的候选者可以在其他队列中研究阅读和语言能力。
Candidate genes have been identified for both reading and language, but most of the heritable variance in these traits remains unexplained. Here, we report a genome-wide association meta-analysis of two large cohorts: population samples of Australian twins and siblings aged 12–25 years (n = 1177 from 538 families), and a younger cohort of children of the UK Avon Longitudinal Study of Parents and their Children (aged 8 and 9 years; maximum n = 5472). Suggestive association was indicated for reading measures and non-word repetition (NWR), with the greatest support found for single nucleotide polymorphisms (SNPs) in the pseudogene, ABCC13 (P = 7.34 × 10−8), and the gene, DAZAP1 (P = 1.32 × 10−6). Gene-based analyses showed significant association (P < 2.8 × 10−6) for reading and spelling with genes CD2L1, CDC2L2 and RCAN3 in two loci on chromosome 1. Some support was found for the same SNPs having effects on both reading skill and NWR, which is compatible with behavior genetic evidence for influences of reading acquisition on phonological-task performance. The results implicate novel candidates for study in additional cohorts for reading and language abilities.
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