Hnf1beta and nephron segmentation.
Hnf1beta and nephron segmentation.
复制标题
DOI：
10.1007/s00467-013-2662-x
复制
发表时间：
2014-04
影响因子：
3
通讯作者：
Davidson, Alan J.
中科院分区：
文献类型：
--
作者：
Naylor, Richard W.;Davidson, Alan J.
The nephron is the functional unit that executes the homeostatic roles of the kidney in vertebrates. Critical to this function is the physical arrangement of the glomerular blood filter attached to a tubular epithelium that is subdivided into specialized proximal and distal segments. During embryogenesis, nephron progenitors undergo a mesenchymal-epithelial transition (MET) and adopt different segment-specific cell fates along the proximo-distal axis of the nephron. The molecular basis of how these segments arise remains largely unknown. Recent studies using the zebrafish identified the Hnf1beta transcription factor (Hnf1b) as a major regulator of tubular segmentation. In Hnf1b-deficient zebrafish embryos, nephron progenitors fail to adopt the proximo-distal segmentation pattern of the nephron, yet still undergo MET. This observation suggests that the functional segmentation of renal tubular epithelial cells is independent of pathways that induce their epithelialization. Here we review this new role of Hnf1b for nephron segmentation during zebrafish and mouse kidney development.
登录
查看更多内容
影响因子：
3.5
作者：
Edghill, E. L.;Stals, K.;Ellard, S.
通讯作者：
Ellard, S.
影响因子：
3.6
作者：
Kikuchi, Ryota;Kusuhara, Hiroyuki;Sugiyama, Yuichi
通讯作者：
Sugiyama, Yuichi
影响因子：
19.6
作者：
Cheng, HT;Kopan, R
通讯作者：
Kopan, R
影响因子：
13.6
作者：
Naylor, Richard W.;Przepiorski, Aneta;Davidson, Alan J.
通讯作者：
Davidson, Alan J.
影响因子：
3.8
作者：
Auyeung, DJ;Kessler, FK;Ritter, JK
通讯作者：
Ritter, JK