Synthesis of 4,5-diaminopyrrolo[1,2-a]quinoline derivatives by annulation of N,N-dialkyl [2-(pyrrol-1-yl)benzylidene]ammonium salts in the presence of an isocyanide
Synthesis of 4,5-diaminopyrrolo[1,2-a]quinoline derivatives by annulation of N,N-dialkyl [2-(pyrrol-1-yl)benzylidene]ammonium salts in the presence of an isocyanide
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DOI：
10.1016/j.tet.2006.08.089
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发表时间：
2006-10-29
期刊：
影响因子：
2.1
通讯作者：
Konishi, Hisatoshi
中科院分区：
文献类型：
--
作者：
Kobayashi, Kazuhiro;Takanohashi, Atsushi;Konishi, Hisatoshi
提出了一种合成4，5-二氨基吡咯并[1，2-a]喹啉衍生物的简便方法。在异氰基化合物存在下，2-(吡咯基-1-基)苯甲醛与仲胺盐酸盐/NaI/TmCl/Et3N反应生成4-烷基(或aryl)amino-5-dialkylaminopyr-rolo[1，2-a]quinolines.(C)2006爱思唯尔有限公司。保留所有权利。
A facile synthetic method for 4,5-diaminopyrrolo[1,2-a]quinoline derivatives has been developed. Treatment of 2-(pyrrol-1-yl)-benzaldehydes with secondary amine hydrochloride/NaI/TMSCl/Et3N in the presence of an isocyano compound leads to the formation of 4-alkyl(or aryl)amino-5-dialkylaminopyr-rolo[1,2-a]quinolines. (c) 2006 Elsevier Ltd. All rights reserved.