HEART DEVELOPMENT IN DROSOPHILA AND ITS RELATIONSHIP TO VERTEBRATES
HEART DEVELOPMENT IN DROSOPHILA AND ITS RELATIONSHIP TO VERTEBRATES
复制标题
DOI：
10.1016/1050-1738(94)00032-q
复制
发表时间：
1995-01-01
影响因子：
9.3
通讯作者：
BODMER, R
中科院分区：
文献类型：
--
作者：
BODMER, R
脊椎动物 hox 基因簇及其与果蝇 HOM-C 同源异型基因簇的结构和功能关系的发现揭示了脊椎动物和许多无脊椎动物（可能包括所有多细胞生物）形成主要身体轴的发育机制之间惊人的相似性。最近的数据表明，果蝇的心脏发育在几个基本方面也类似于脊椎动物的心脏发育，尽管它们之间存在巨大的形态差异。同源框基因tinman在果蝇胚胎心脏中表达并且是心脏形成所必需的，其发现使得比较果蝇和脊椎动物心脏发育的决定因素成为可能。锡曼与小鼠、青蛙和鱼类有相当大的序列相似性，并且这些基因之一也在发育中的心脏中特异性表达。心脏祖细胞的胚胎学起源和形态发生运动，以及基因表达模式和可能的功能，在果蝇和脊椎动物中似乎是相似的。如果果蝇和脊椎动物之间的心脏发育确实是保守的，那么果蝇可以再次作为脊椎动物发育的模型系统。
The discovery of the vertebrate hox gene clusters and their structural and functional relationship to the Drosophila HOM-C cluster of homeotic genes revealed amazing similarities between the developmental mechanisms by which a major body axis is formed in vertebrates and those of many invertebrates, possibly encompassing all multicellular organisms. Recent data suggest that heart development in Drosophila also resembles vertebrate heart development in several fundamental aspects despite the drastic morphologic differences between them. The discovery of the homeobox gene tinman, which is expressed in the embryonic heart of Drosophila and is required for heart formation, made it possible to compare the determining factors of heart development between Drosophila and vertebrates. tinman has mouse, frog, and fish relatives with considerable sequence similarity, and one of these genes is also specifically expressed in the developing heart. It appears that embryologic origins and morphogenic movements of heart progenitors, as well as gene expression patterns and possibly their functions, are similar in Drosophila and in vertebrates. If it is true that heart development is conserved between Drosophila and vertebrates, then Drosophila, once again, could serve as a model system for vertebrate development.