A multi-scale cholera model linking between-host and within-host dynamics
A multi-scale cholera model linking between-host and within-host dynamics
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DOI：
10.1142/s1793524518500341
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发表时间：
2018-04
影响因子：
2.2
通讯作者：
Chayu Yang;Drew Posny;Feng Bao;Jin Wang
中科院分区：
文献类型：
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作者：
Chayu Yang;Drew Posny;Feng Bao;Jin Wang
我们提出了一个多尺度建模框架来研究霍乱的传播动力学。在种群水平上，我们采用SIR模型来研究该疾病在宿主之间的传播。在个体宿主水平上，我们描述了病原体在人体内的进化。宿主间和宿主内的动态通过表征病原体生长及其与人体外宿主相互作用的环境方程联系起来。我们通过对每个单独的宿主进行区分，特别强调了宿主内部的动态。我们对我们的模型进行数学分析和数值模拟，以探索与霍乱传播相关的各种情况，并更好地理解复杂的多尺度疾病动力学。
We propose a multi-scale modeling framework to investigate the transmission dynamics of cholera. At the population level, we employ a SIR model for the between-host transmission of the disease. At the individual host level, we describe the evolution of the pathogen within the human body. The between-host and within-host dynamics are connected through an environmental equation that characterizes the growth of the pathogen and its interaction with the hosts outside the human body. We put a special emphasis on the within-host dynamics by making a distinction for each individual host. We conduct both mathematical analysis and numerical simulation for our model in order to explore various scenarios associated with cholera transmission and to better understand the complex, multi-scale disease dynamics.