Synthesis of Chiral β-Amino Nitroalkanes via Rhodium-Catalyzed Asymmetric Hydrogenation
Synthesis of Chiral β-Amino Nitroalkanes via Rhodium-Catalyzed Asymmetric Hydrogenation
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铑催化不对称氢化合成手性β-氨基硝基烷烃
DOI：
10.1021/acs.orglett.5b03158
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发表时间：
2016-01-01
期刊：
影响因子：
5.2
通讯作者：
Zhang, Xumu
中科院分区：
文献类型：
--
作者：
Li, Pan;Zhou, Ming;Zhang, Xumu
以铑/双膦硫脲L-1为催化剂，在温和条件下成功地实现了β-氨基硝基烯烃的不对称加氢反应，对映选择性和收率均达到96% ee，收率96%，转化率>99%，TON高达1000。手性β-氨基硝基烷烃及其衍生物是一类用途广泛的有机合成中间体。
The asymmetric hydrogenation of beta-amino nitroolefins has been successfully achieved by rhodium/bis(phosphine)-thiourea L-1 with excellent enantioselectivities and yields (up to 96% ee, 96% yield, >99% conversion, TON up to 1000) under mild conditions. Chiral beta-amino nitroalkane products and their derivatives are versatile intermediates in organic synthesis.