HISTOPATHOLOGY OF MULTIPLE-SCLEROSIS LESIONS DETECTED BY MAGNETIC-RESONANCE-IMAGING IN UNFIXED POSTMORTEM CENTRAL-NERVOUS-SYSTEM TISSUE
HISTOPATHOLOGY OF MULTIPLE-SCLEROSIS LESIONS DETECTED BY MAGNETIC-RESONANCE-IMAGING IN UNFIXED POSTMORTEM CENTRAL-NERVOUS-SYSTEM TISSUE
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DOI：
10.1093/brain/114.2.1013
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发表时间：
1991-04-01
期刊：
影响因子：
14.5
通讯作者：
MCDONALD, WI
中科院分区：
文献类型：
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作者：
NEWCOMBE, J;HAWKINS, CP;MCDONALD, WI
对17例多发性硬化患者和6例正常对照者的尸检非固定全脑进行了磁共振成像（MRI）检查，采用T2加权自旋回波序列和组织学检查，以确定MRI异常信号区域与潜在病理变化之间的关系。 在第1组中，在5个大脑中，在组织学上检测到小的MRI病变和相应的小斑块，其中大部分是慢性的。 在4个脑中，存在更广泛的异常信号和组织学斑块区域，这些区域更经常活动（组2）。 然而，在另外5个大脑中，当组织学上仅存在小的室周斑块时，观察到广泛的MRI异常（组3）。 MRI很少观察到后脑和大脑灰质的病变。 在仅发现小的组织学斑块的区域中观察到的广泛的MRI异常可能是斑块周围正常外观的白色物质的血管通透性改变的结果。
Postmortem unfixed whole brains from 17 multiple sclerosis and 6 control cases were examined by magnetic resonance imaging (MRI) using a T2-weighted spin echo sequence and histology to determine the relationship between areas of abnormal MRI signal and underlying pathological change. In group 1, small MRI lesions and correspondingly small plaques, most of which were chronic, were detected histologically in 5 brains. In 4 brains there were more extensive areas of both abnormal signal and histological plaques which were more often active (group 2). However, in a further 5 brains extensive MRI abnormalities were observed when only small periventricular plaques were present histologically (group 3). Lesions in the hindbrain and cerebral grey matter were infrequently observed by MRI. The extensive MRI abnormalities seen in areas in which only small histological plaques were found may be the result of vascular permeability changes in the normal-appearing white matter surrounding plaques.