Prolonged central sensory conduction time in patients with chronic arsenic exposure
Prolonged central sensory conduction time in patients with chronic arsenic exposure
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DOI：
10.1016/j.jns.2015.12.020
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发表时间：
2016-02-15
影响因子：
4.4
通讯作者：
Nakazato, Masamitsu
中科院分区：
文献类型：
--
作者：
Mochizuki, Hitoshi;Yagi, Kazuhiro;Nakazato, Masamitsu
背景：来自日本得六市的许多长期砷暴露的患者表现出全身感觉障碍，四肢更为明显。尽管之前对该人群的研究显示其患有轻度周围神经病变，但尚不清楚这些患者是否患有中枢神经系统损伤。为了调查与慢性砷中毒相关的感觉障碍的病变部位，我们分析了体感诱发电位（SEP）。方法：回顾性分析慢性砷暴露患者的临床特征、神经传导研究结果以及中位和/或胫骨SEP（总共13例；中位和胫骨，4例；中位，5例；胫骨，4例）。将患者的 SEP 结果与正常对照进行比较。结果：中位 SEP 结果表明近端臂丛神经和初级感觉皮层之间存在传导延迟，胫骨 SEP 结果表明腰骶索背侧灰质与初级感觉皮层之间存在传导延迟。结论：这是第一项发现慢性砷暴露患者中枢体感通路受损的研究。这些患者的感觉障碍不仅与周围神经病变有关，还与中枢神经系统损伤有关。 (C) 2015 年作者。由 Elsevier B.V. 出版
Background: Many patients from Toroku, Japan, who have chronic arsenic exposure demonstrate whole-body sensory disturbance that is slightly more pronounced in the extremities. Although previous research in this population showed a mild peripheral neuropathy, it is unknown whether these patients have central nervous system impairment. To investigate the lesion sites underlying sensory disturbance related to chronic arsenic poisoning, we analyzed somatosensory evoked potentials (SEP).Methods: Clinical features, nerve conduction study results, and median and/or tibial SEP were analyzed in patients with chronic arsenic exposure (total, 13 patients; median & tibial, 4; median, 5; tibial, 4) retrospectively. The SEP findings in patients were compared with those in normal controls.Results: The median SEP results indicated a conduction delay between the proximal brachial plexus and the primary sensory cortex, and tibial SEP findings indicated a delay between the dorsal gray matter of the lumbosacral cord and the primary sensory cortex.Conclusion: This is the first study to identify an impairment of the central somatosensory pathway in patients with chronic arsenic exposure. Sensory disturbance in these patients is related not only to peripheral neuropathy but also to impairment of the central nervous system. (C) 2015 The Authors. Published by Elsevier B.V.