The great migration of Bax and Bak
The great migration of Bax and Bak
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DOI：
10.4161/23723556.2014.995029
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发表时间：
2015-01-01
影响因子：
2.1
通讯作者：
Edlich, Frank
中科院分区：
文献类型：
--
作者：
Edlich, Frank
Bcl-2蛋白Bcl-2相关X蛋白（Bax）和Bcl-2拮抗剂杀伤1（巴克）可使细胞凋亡。Bax从线粒体到胞质溶胶的逆向易位对于细胞存活是必不可少的。最近，我们报道了巴克也存在于健康细胞的胞质溶胶中，并且Bax和巴克受相同的逆转录过程调节。
The Bcl-2 proteins Bcl-2-associated X protein (Bax) and Bcl-2 antagonist killer 1 (Bak) can commit cells to apoptosis. Retrotranslocation of Bax from the mitochondria into the cytosol is essential for cell survival. Recently, we reported that Bak is also present in the cytosol of healthy cells and that Bax and Bak are regulated by the same retrotranslocation process.