THE THYMUS HAS 2 FUNCTIONALLY DISTINCT POPULATIONS OF IMMATURE ALPHA-BETA+T-CELLS - ONE POPULATION IS DELETED BY LIGATION OF ALPHA-BETA-TCR
THE THYMUS HAS 2 FUNCTIONALLY DISTINCT POPULATIONS OF IMMATURE ALPHA-BETA+T-CELLS - ONE POPULATION IS DELETED BY LIGATION OF ALPHA-BETA-TCR
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DOI：
10.1016/0092-8674(89)90503-5
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发表时间：
1989-09-22
期刊：
影响因子：
64.5
通讯作者：
KAPPLER, JW
中科院分区：
文献类型：
--
作者：
FINKEL, TH;CAMBIER, JC;KAPPLER, JW
在T细胞发育过程中，选择和耐受过程作用于胸腺皮层中表达的T细胞受体，形成成熟的T细胞库，这些T细胞将在该动物的自我mhc背景下对外来抗原作出反应。我们将皮质胸腺细胞细分为三个功能不同的群体：一个群体是抗原受体阴性的，第二个群体是抗原受体阳性的，通过抗原受体发出信号来抵抗删除，第三个群体也是抗原受体阳性的，但对删除敏感。这些结果对发生正选择和负选择的细胞区室以及介导选择和耐受性的生化机制具有启示意义。
During T cell development, the processes of selection and tolerance act on the universe of expressed T cell receptors in the thymic cortex to form the repertoire of mature T cells that will respond to foreign antigen in the context of self-MHC in that animal. We have subdivided the cortical thymocytes into three functionally distinct populations: one population which is antigen-receptor negative, a second population which is antigen-receptor positive and is resistant to deletion by signaling through the antigen receptor, and a third population which is also antigen-receptor positive but is sensitive to deletion. These results have implications for the cellular compartments in which positive and negative selection occur and for the biochemical mechanisms that mediate selection and tolerance.