Candida auris in Healthcare Facilities, New York, USA, 2013-2017
Candida auris in Healthcare Facilities, New York, USA, 2013-2017
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DOI：
10.3201/eid2410.180649
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发表时间：
2018-10-01
影响因子：
11.8
通讯作者：
Zucker, Howard
中科院分区：
文献类型：
--
作者：
Adams, Eleanor;Quinn, Monica;Zucker, Howard
耳念珠菌是一种新兴的酵母菌，可引起医疗保健相关感染。它可能会被实验室错误识别，并且通常对抗真菌药物具有抗药性。我们描述了美国纽约州纽约市医疗机构中耳念珠菌感染的爆发。调查包括实验室监测、记录审查、现场访问、培养接触者追踪和环境采样。我们确定了 51 名临床病例和 61 名筛查病例。流行病学联系表明，整个纽约市受影响的医疗机构有一个庞大的、相互关联的网络。 51例临床病例中，90天内死亡23例（45%），分离株对氟康唑耐药50例（98%）。在对 572 人（总共 1,136 份培养物）进行的筛查培养中，61 人（11%）的结果为耳念珠菌阳性。 20 个设施中有 15 个的环境培养样本呈阳性。在接触者调查期间经常发现定植；环境污染也很常见。
Candida auris is an emerging yeast that causes healthcare-associated infections. It can be misidentified by laboratories and often is resistant to antifungal medications. We describe an outbreak of C. auris infections in healthcare facilities in New York City, New York, USA. The investigation included laboratory surveillance, record reviews, site visits, contact tracing with cultures, and environmental sampling. We identified 51 clinical case-patients and 61 screening case-patients. Epidemiologic links indicated a large, inter-connected web of affected healthcare facilities throughout New York City. Of the 51 clinical case-patients, 23 (45%) died within 90 days and isolates were resistant to fluconazole for 50 (98%). Of screening cultures performed for 572 persons (1,136 total cultures), results were C. auris positive for 61 (11%) persons. Environmental cultures were positive for samples from 15 of 20 facilities. Colonization was frequently identified during contact investigations; environmental contamination was also common.