Freeze-fracture studies of muscle caveolae in human muscular dystrophy.
Freeze-fracture studies of muscle caveolae in human muscular dystrophy.
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发表时间：
1981-08
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通讯作者：
E. Bonilla;K. Fischbeck;D. Schotland
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作者：
E. Bonilla;K. Fischbeck;D. Schotland
用冷冻断裂法研究了6例Duchenne型肌营养不良症（DMD）、5例面肩肱型肌营养不良症（FSH）、5例强直性肌营养不良症（MyD）和5例正常人骨骼肌质膜小窝密度和分布。结果显示，DMD患者的肌细胞膜中的小窝数量显著增加，大小减小。在FSH和MyD患者的肌肉质膜中未观察到微囊的显著变化。
Freeze-fracture studies of caveolar density and distribution were carried out in skeletal muscle plasma membrane from 6 patients with Duchenne muscular dystrophy (DMD), 5 patients with facioscapulohumeral dystrophy (FSH), 5 patients with myotonic dystrophy (MyD) and 5 normal control subjects. The results showed a significant increase in the number of caveolae and a decrease in size in a population of muscle plasma membranes from patients with DMD. No significant changes in the caveolae were observed in muscle plasma membranes from patients with FSH and MyD.