Interactions between CYP3A4 and Dietary Polyphenols.
Interactions between CYP3A4 and Dietary Polyphenols.
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DOI：
10.1155/2015/854015
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发表时间：
2015
影响因子：
--
通讯作者：
Kerem Z
中科院分区：
文献类型：
--
作者：
Basheer L;Kerem Z
人细胞色素P450酶（P450）催化广谱底物的氧化反应，并在异生物质（如药物和膳食化合物）的代谢中起关键作用。已知CYP 3A 4是参与药物和大多数其他外源性物质代谢的主要酶。膳食化合物，其中多酚是研究最多的，已被证明与CYP 3A 4相互作用，并改变其表达和活性。传统上，肝脏被认为是CYP 3A介导的首过代谢提取的主要部位，但体外和体内研究现在表明，小肠对多酚和药物的代谢具有同等或更大的重要性。最近的研究指出，肠道微生物群在人体多酚代谢命运中的作用，表明它们参与了膳食多酚和CYP 3A 4之间复杂的相互作用。最后但并非最不重要的是，所有上述表明，共同施用富含多酚的药物和食物预计会刺激不良的临床后果。本文综述了膳食多酚和CYP 3A 4之间的相互作用，因为它们涉及到结构上的考虑，食品-药物相互作用，以及CYP 3A 4和多酚之间的相互作用的潜在负面后果。
The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as drugs and dietary compounds. CYP3A4 is known to be the main enzyme involved in the metabolism of drugs and most other xenobiotics. Dietary compounds, of which polyphenolics are the most studied, have been shown to interact with CYP3A4 and alter its expression and activity. Traditionally, the liver was considered the prime site of CYP3A-mediated first-pass metabolic extraction, but in vitro and in vivo studies now suggest that the small intestine can be of equal or even greater importance for the metabolism of polyphenolics and drugs. Recent studies have pointed to the role of gut microbiota in the metabolic fate of polyphenolics in human, suggesting their involvement in the complex interactions between dietary polyphenols and CYP3A4. Last but not least, all the above suggests that coadministration of drugs and foods that are rich in polyphenols is expected to stimulate undesirable clinical consequences. This review focuses on interactions between dietary polyphenols and CYP3A4 as they relate to structural considerations, food-drug interactions, and potential negative consequences of interactions between CYP3A4 and polyphenols.
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DOI：
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发表时间：
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期刊：
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