HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads
HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads
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DOI：
10.1086/512682
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发表时间：
2007-04-15
影响因子：
6.4
通讯作者：
Overbaugh, Julie
中科院分区：
文献类型：
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作者：
Baeten, Jared M.;Chohan, Bhavna;Overbaugh, Julie
我们调查了人类免疫缺陷病毒1型（HIV-1）亚型对145名肯尼亚妇女的疾病进展的影响，这些妇女是从HIV-1感染开始的。与感染A亚型的妇女相比，感染D亚型的妇女死亡率更高（风险比，2.3 [95%置信区间，1.0-5.6]），CD 4细胞计数下降速度更快（P= 0.003）。校正血浆HIV-1载量后，死亡风险仍然存在。随访期间，HIV-1亚型的血浆病毒载量无差异。尽管血浆HIV-1载量相似，但HIV-1亚型D感染的死亡风险比亚型A感染高12倍。
We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality ( hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P=.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a 12-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.