Supraspinal characterization of the thermal grill illusion with fMRI
Supraspinal characterization of the thermal grill illusion with fMRI
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DOI：
10.1186/1744-8069-10-18
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发表时间：
2014-03-11
期刊：
影响因子：
3.3
通讯作者：
Yaksh, Tony
中科院分区：
文献类型：
--
作者：
Leung, Albert;Shukla, Shivshil;Yaksh, Tony
背景资料：以交错的方式同时呈现无害的温暖（40摄氏度）和寒冷（20摄氏度）刺激会导致短暂的热燃烧的有害感觉（在46摄氏度匹配），称为热格栅（TG）错觉。利用功能性磁共振成像和心理物理评估来比较与三种TG呈现的空间总和效应相关的脊髓上事件：20 ℃/20 ℃（G2020）、20 ℃/40 ℃（G2040）和40 ℃/40 ℃（G4040），以及相应的匹配热电极刺激：结果：G2040仅在初始离线评估时观察到热烧灼感。与P40相比，G4040导致所有脊髓上区域与痛觉/辨别性和伤害性调制反应相关的同等增强的反应。与P20相比，G2020呈递导致更早的减弱/镇静反应，导致由G4040激活的调节性脊髓上区的统计学显著（P < 0.01）更高程度的失活。格兰杰因果关系分析表明，虽然丘脑激活HP可能会造成激活推理的所有热痛相关的躯体感觉，情感和调制区，类似的激活G2040和G2020导致失活inference.Conclusions：总之，短暂的TG感觉是由一个解离状态来自非有害的温暖和寒冷的空间总和的相互作用。所观察到的中枢分离状态可能与某些慢性神经性疼痛状态有一些相似之处。
Background: Simultaneous presentation of non-noxious warm (40 degrees C) and cold (20 degrees C) stimuli in an interlacing fashion results in a transient hot burning noxious sensation (matched at 46 degrees C) known as the thermal grill (TG) illusion. Functional magnetic resonance imaging and psychophysical assessments were utilized to compare the supraspinal events related to the spatial summation effect of three TG presentations: 20 degrees C/20 degrees C (G2020), 20 degrees C/40 degrees C (G2040) and 40 degrees C/40 degrees C (G4040) with corresponding matched thermode stimuli: 20 degrees C (P20), 46 degrees C (P46) and 40 degrees C (P40) and hot pain (HP) stimuli.Results: For G2040, the hot burning sensation was only noted during the initial off-line assessment. In comparison to P40, G4040 resulted in an equally enhanced response from all supraspinal regions associated with both pain sensory/discriminatory and noxious modulatory response. In comparison to P20, G2020 presentation resulted in a much earlier diminished/sedative response leading to a statistically significantly (P < 0.01) higher degree of deactivation in modulatory supraspinal areas activated by G4040. Granger Causality Analysis showed that while thalamic activation in HP may cast activation inference in all hot pain related somatosensory, affective and modulatory areas, similar activation in G2040 and G2020 resulted in deactivation inference in the corresponding areas.Conclusions: In short, the transient TG sensation is caused by a dissociated state derived from non-noxious warm and cold spatial summation interaction. The observed central dissociated state may share some parallels in certain chronic neuropathic pain states.