Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication
Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication
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DOI：
10.1016/j.jvs.2005.01.012
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发表时间：
2005-04-01
影响因子：
4.3
通讯作者：
Katzel, LI
中科院分区：
文献类型：
--
作者：
Izquierdo-Porrera, AM;Gardner, AW;Katzel, LI
目的：本研究的目的是确定外周动脉疾病（PAD）严重程度的功能指标与疾病特异性和一般自我报告的健康相关生活质量（HR-QOL）指标之间的关系，以及两种类型的HR-QOL指标之间的关系。这是个十字架对来自社区和初级保健或血管外科诊所的参与者进行截面观察，中心80例有症状的方丹II期PAD患者提供了生理测量和自我回答问卷。客观指标包括踝臂指数（ABI）、分级运动试验中最大跛行疼痛的时间和6分钟地板步行距离。自我报告包括行走障碍问卷（WIQ），一种疾病特异性HR-QOL测量和医学结局研究（MOS）简表36（SF-36），一种通用HR-QOL测量。患者（平均年龄70 +/- 8 [+/- SD]和85%的男性）通过ABI的客观测量显示中度至重度PAD（0.65 +/- 0.19）和分级运动试验中最大跛行时间（分钟）（7：54 +/- 4：58）。这些措施和WIQ距离，MOS-身体功能，和MOS-角色限制，由于身体功能障碍之间的显着相关性。SF-36和WIQ分量表显着correlated.Conclusion：在老年PAD患者间歇性跛行，疾病严重程度的客观措施与自我报告，疾病特异性和通用HR-QOL。
Objectives: The aim of this study was to determine the relation between functional measures of peripheral arterial disease (PAD) severity with both disease-specific and generic self-reported health-related quality-of-life (HR-QOL) measures, as well as the relation between the two types of HR-QOL measures.Methods: This was a cross-sectional observation of participants from the community and primary care or vascular surgery clinics in an academic Veterans Administration medical center. Eighty patients with symptomatic Fontaine stage II PAD provided physiologic measures and self-response questionnaires. Objective measures included the ankle-brachial index (ABI), time to maximum claudication pain on a graded exercise test, and a 6-minute floor-walking distance. Self-reports included the Walking Impairment Questionnaire (WIQ), a disease-specific HR-QOL measure and the Medical Outcomes Study (MOS) Short-Form 36 (SF-36), a generic HR-QOL measure.Results: Patients (mean age 70 +/- 8 [+/- SD] and 85% men) exhibited moderate-to-severe PAD by objective measures of ABI (0.65 +/- 0.19) and time in minutes to maximal claudication on a graded exercise test (7:54 +/- 4:58). Significant correlations were found between these measures and the WIQ distance, MOS-Physical Function, and MOS-Role Limitations due to physical dysfunction. The SF-36 and the WIQ subscales were significantly correlated.Conclusion: In older PAD patients with intermittent claudication, objective measures of disease severity are correlated with a self-reported, disease-specific and generic HR-QOL.