Drugs with anticholinergic properties as a risk factor for psychosis in patients affected by Alzheimer's disease
Drugs with anticholinergic properties as a risk factor for psychosis in patients affected by Alzheimer's disease
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DOI：
10.1038/sj.clpt.6100435
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发表时间：
2008-07-01
影响因子：
6.7
通讯作者：
Gigli, G. L.
中科院分区：
文献类型：
--
作者：
Cancelli, I.;Valentinis, L.;Gigli, G. L.
新的证据表明，阿尔茨海默病 (AD) 患者的精神病可能与该疾病相关的胆碱能缺陷有关。本研究旨在评估抗胆碱能（ACH）药物是否可能是精神病发作的危险因素。总共招募了 230 名可能患有 AD 的患者。使用神经精神病学调查表收集行为和心理症状的数据，并进行精神病诊断。患者分为使用 ACH 药物的患者和使用非 ACH 药物的患者。使用 ACH 药物的患者 (18.3%) 比使用非 ACH 药物的患者更容易患精神病（比值比 (OR) 2.52；95% 置信区间 (CI)，1.27-5.00）；即使在调整了潜在的混杂变量后，这种关联仍然显着（OR 2.13；95% CI，1.03-4.43）。我们的数据表明，AD 患者经常接受 ACH 药物治疗，ACH 药物的摄入应被视为精神病的潜在危险因素。
Emerging evidence suggests that psychosis in persons with Alzheimer's disease (AD) may be linked to the cholinergic deficit associated with the disease. This study sought to evaluate whether anticholinergic (ACH) drugs could be a risk factor for psychosis onset. A total of 230 patients affected with probable AD were recruited. Data on behavioral and psychological symptoms were collected using the Neuropsychiatric Inventory, and diagnosis of psychosis was performed. Patients were divided into those who used ACH drugs and those who used non-ACH drugs. Those using ACH drugs (18.3%) were more likely to have psychosis than those using non-ACH drugs (odds ratio (OR) 2.52; 95% confidence interval (CI), 1.27-5.00); this association remained significant even after adjusting for potential confounding variables (OR 2.13; 95% CI, 1.03-4.43). Our data suggest that patients with AD are frequently treated with ACH drugs and that ACH drug intake should be regarded as a potential risk factor for psychosis.