Expression of Fc epsilon receptor I on primary sensory neurons in mice
Expression of Fc epsilon receptor I on primary sensory neurons in mice
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DOI：
10.1097/00001756-200409150-00007
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发表时间：
2004-09-15
期刊：
影响因子：
1.7
通讯作者：
Kuraishi, Y
中科院分区：
文献类型：
--
作者：
Andoh, T;Kuraishi, Y
我们研究了IgE受体是否在小鼠感觉神经元上表达。免疫染色结果显示，高亲和力IgE受体FcepsilonRI在培养的背根神经节细胞中表达，FcepsilonRI免疫反应细胞以泛神经元标记蛋白基因产物9.5阳性为主。许多fcepsilonri免疫反应神经元大小较小或中等。IgE能与培养的神经元结合，但不能与神经节的神经胶质细胞结合。fcepsiloni免疫反应细胞对高亲和力IgG受体FcgammaRI也呈阳性。FcepsilonRI的表达量低于FcgammaRI。fcepsilonri样免疫反应性局限于皮肤神经纤维。结果表明，IgE直接作用于初级感觉神经元和肥大细胞。
We investigated whether IgE receptors are expressed on sensory neurons in mice. Immunostaining revealed that the high affinity IgE receptor FcepsilonRI was expressed in cultured dorsal root ganglion cells and that FcepsilonRI-immunoreactive cells were mainly positive for the pan-neuronal marker protein gene product 9.5. Many FcepsilonRI-immunoreactive neurons were small or medium in size. IgE was bound to cultured neurons but not glial cells from the ganglia. FcepsilonRI-immunoreactive cells were also positive for the high affinity IgG receptor FcgammaRI. The expression level of FcepsilonRI was lower than that of FcgammaRI. FcepsilonRI-like immunoreactivity was localized on nerve fibers in the skin. The results suggest that IgE acts directly on primary sensory neurons as well as mast cells.