Intratumoural level of SDF-1 correlates with survival in head and neck squamous cell carcinoma
Intratumoural level of SDF-1 correlates with survival in head and neck squamous cell carcinoma
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DOI：
10.1016/j.oraloncology.2011.07.021
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发表时间：
2011-11-01
期刊：
影响因子：
4.8
通讯作者：
Laberge-Le-Couteulx, Sophie
中科院分区：
文献类型：
--
作者：
Clatot, Florian;Picquenot, Jean-Michel;Laberge-Le-Couteulx, Sophie
SDF-1/CXCR 4通路已被认为在各种肿瘤的转移性传播中发挥作用。我们评估了SDF-1和CXCR 4表达对头颈部鳞状细胞癌（HNSCC）预后的影响。回顾性分析了71例在初次诊断时收集的HNSCC样本。SDF-1和CXCR 4表达水平采用实时RT-PCR测定，并与生存率相关。中位随访45个月后，25例患者（35%）死于癌症（D组），46例患者（65%）存活或死亡，无HSNCC进展证据（A组）。CXCR 4表达的中位数水平在A组和D组分别为0.33和0.29（P = 0.93），显示与复发或生存无关。相比之下，SDF-1表达的中位水平在A组和D组中有显著差异（分别为2.41 vs 1.16，P = 0.018）。以中位水平为界值，SDF-1水平低的患者的无转移（P = 0.026）、无疾病（P = 0.006）和总体特异性生存率（P = 0.002）较差。多因素分析证实SDF-1的预后价值。在这一系列的71例HNSCC患者中，SDF-1表达水平与转移进展和总生存率显著相关。(C)2011爱思唯尔有限公司保留所有权利。
The SDF-1/CXCR4 pathway has been suggested to play a role in the metastatic dissemination of various tumours. We assessed the prognostic impact of SDF-1 and CXCR4 expression in head and neck squamous cell carcinoma (HNSCC). Seventy-one HNSCC samples collected at the time of initial diagnosis were retrospectively analysed. SDF-1 and CXCR4 expression levels were measured using real-time RT-PCR and correlated to survival. After a median follow-up of 45 months, 25 patients (35%) died of cancer (group D), and 46 patients (65%) were alive or dead without evidence of HSNCC evolution (group A). The median level of CXCR4 expression was 0.33 and 0.29 in groups A and D, respectively (P = 0.93), showing no correlation with recurrence or survival. By contrast, the median level of SDF-1 expression was significantly different in the A and D groups (2.41 vs 1.16, respectively, P = 0.018). Using the median level as a cut-off, patients with low SDF-1 had poorer metastasis-free (P = 0.026), disease-free (P = 0.006) and overall specific survival rates (P = 0.002). The prognostic value of SDF-1 was confirmed by a multivariate analysis. In this series of 71 HNSCC patients, the SDF-1 expression level correlated significantly with metastatic evolution and overall survival. (C) 2011 Elsevier Ltd. All rights reserved.