Reduced Dorsal Prefrontal Gray Matter After Chronic Ketamine Use
Reduced Dorsal Prefrontal Gray Matter After Chronic Ketamine Use
复制标题
长期使用氯胺酮后背侧前额叶灰质减少
DOI：
10.1016/j.biopsych.2010.08.030
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发表时间：
2011-01-01
影响因子：
10.6
通讯作者：
Fletcher, Paul C.
中科院分区：
文献类型：
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作者：
Liao, Yanhui;Tang, Jinsong;Fletcher, Paul C.
背景：氯胺酮作为一种娱乐性药物在世界各地的年轻人中迅速蔓延。流行病学研究表明，长期使用氯胺酮与许多问题有关，包括认知障碍、膀胱功能障碍和氯胺酮相关死亡。然而，关于氯胺酮使用对大脑结构和功能的长期影响知之甚少。方法：我们使用基于体素的形态测量结合统计参数映射对凯塔依赖者（n = 41）和药物初治对照者（n = 44）的结构磁共振图像进行评估，以评估两组之间灰质体积的差异。我们观察到氯胺酮使用者的双侧额叶皮质（左侧上级回和右侧额中回）的灰质体积与对照受试者相比显著减少（p <0.05，经聚类水平的多重比较校正）。氯胺酮使用的持续时间呈负相关，双侧额叶皮质的灰质体积，而估计的总寿命氯胺酮的消费量呈负相关，左额上级gyrus.Conclusions灰质体积：我们已经证明了减少慢性氯胺酮使用后，患者的额叶灰质体积。额叶灰质衰减与氯胺酮使用持续时间和氯胺酮累积剂量之间的联系可能表明长期使用该药物的剂量依赖性效应。我们的研究结果具有重要的内涵的临床图片，可能会出现越来越多的娱乐使用氯胺酮，也是有关的药物作为精神分裂症的模型的地位。
Background: Use of ketamine as a recreational drug is spreading rapidly among young people all over the world. Epidemiological studies have linked chronic ketamine use with a number of problems, including cognitive impairments, bladder dysfunction, and ketamine-related death. However, little is known about the long-term effects of ketamine use on brain structure and function.Methods: We used voxel based morphometry in conjunction with statistical parametric mapping on the structural magnetic resonance images of keta mine-dependent (n = 41) and drug-naive control individuals (n = 44) to assess differences in gray matter volume between the two groups.Results: We observed significant decreases in gray matter volume in bilateral frontal cortex (left superior frontal gyrus and right middle frontal gyrus) of ketamine users in comparison with control subjects (p < .05 corrected for multiple comparisons at cluster-level). Duration of ketamine use was negatively correlated with gray matter volume in bilateral frontal cortex, whereas the estimated total lifetime ketamine consumption was negatively correlated with gray matter volume in left superior frontal gyrus.Conclusions: We have demonstrated a reduction in frontal gray matter volume in patients after chronic ketamine use. The link between frontal gray matter attenuation and the duration of ketamine use and cumulative doses of ketamine perhaps suggests a dose-dependent effect of long-term use of the drug. Our results have important connotations for the clinical picture that is likely to emerge with the growing recreational use of ketamine and is also relevant to the status of the drug as a model for schizophrenia.