31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy
31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy
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DOI：
10.1161/01.cir.97.25.2536
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发表时间：
1998-06-30
期刊：
影响因子：
37.8
通讯作者：
Dietze, GJ
中科院分区：
文献类型：
--
作者：
Jung, WI;Sieverding, L;Dietze, GJ
背景：肥厚型心肌病 (HCM) 经常导致青少年和年轻人突然、意外死亡。心肌代谢的改变被认为是收缩功能障碍的原因。我们研究了 HCM 患者的代谢异常是否先于症状表现的问题。方法和结果 - 使用 1.5-T 全身成像仪对 14 名年轻无症状 HCM 患者的心脏前左心室壁进行质子解耦 P-31 NMR 波谱分析。将磷酸盐代谢物的光谱与正常对照受试者的光谱进行比较。患者表现出显着降低（P
Background-Hypertrophic cardiomyopathy (HCM) often causes sudden, unexpected death in adolescents and young adults. Alterations in myocardial metabolism are considered to be causes for contractile dysfunction. We examined the question of whether metabolic abnormalities antedate the manifestation of symptoms in patients with HCM.Methods and Results-Proton-decoupled P-31 NMR spectroscopy of the anterior left ventricular wall of the heart of 14 young, asymptomatic patients with HCM was performed with a 1.5-T whole-body imager. Spectra of the phosphate metabolites were compared with those of normal control subjects. The patients exhibited a significantly reduced (P