SELECTIVE REDUCTION OF DISULFIDES BY TRIS(2-CARBOXYETHYL)PHOSPHINE
SELECTIVE REDUCTION OF DISULFIDES BY TRIS(2-CARBOXYETHYL)PHOSPHINE
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DOI：
10.1021/jo00008a014
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发表时间：
1991-04-12
影响因子：
3.6
通讯作者：
WHITESIDES, GM
中科院分区：
文献类型：
--
作者：
BURNS, JA;BUTLER, JC;WHITESIDES, GM
三（2-羧乙基）膦（TCEP）在pH 4.5的水中快速完全还原二硫化物。 它优先减少更多的应变二硫化物，根据通常的机制，假定为减少二硫化物的膦在水中。 该试剂可通过市售三（2-氰乙基）膦的酸水解方便地大量合成。
Tris(2-carboxyethyl)phosphine (TCEP) reduces disulfides rapidly and completely in water at pH 4.5. It preferentially reduces more strained disulfides, in accordance with the usual mechanism postulated for reduction of disulfides by phosphines in water. The reagent can be synthesized conveniently in large quantities by acidic hydrolysis of the commercially available tris(2-cyanoethyl)phosphine.