The potential role of endocrine disrupting chemicals in cellulite
The potential role of endocrine disrupting chemicals in cellulite
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DOI：
10.1016/j.mehy.2018.05.008
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发表时间：
2018-07-01
影响因子：
4.7
通讯作者：
Mazioti, Maria
中科院分区：
文献类型：
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作者：
Mazioti, Maria
脂肪团是影响大多数青春期后女性的主要美学问题。目前流行病学证据支持脂肪团的患病率在工业化社会中显着较高，表明环境因素在其发病机制和延续中起着至关重要的作用。环境中普遍存在的内分泌干扰化学品能够改变激素和体内平衡系统。它们中的一些通过结合雌激素受体并模拟雌激素的生物活性来发挥激动剂作用。由于升高的雌激素浓度是脂肪团的先决条件，本文表明，内分泌干扰化学物质可能是脂肪团的启动和恶化的关键决定因素，无论是通过刺激雌激素受体或增加其循环水平，由于干扰酶和结合蛋白。
Cellulite constitutes a major aesthetic concern affecting the majority of post-adolescent women. Current epidemiological evidence supports that the prevalence of cellulite is significantly higher in industrialized societies indicating that environmental factors have crucial role in its pathogenesis and perpetuation. Endocrine disrupting chemicals, which exist ubiquitously in the environment, are able to alter hormonal and homeostatic systems. Several of them exert agonist effects by binding to estrogen receptors and mimicking the biological activity of estrogens. Since elevated estrogen concentration is prerequisite for cellulite, the present article suggests that endocrine disrupting chemicals may be key determinants in the initiation and deterioration of cellulite either by stimulating estrogen receptors or increasing their circulating levels due to interference with enzymes and binding proteins.