Effects of zinc deficiency and supplementation on plasma leptin levels in rats
Effects of zinc deficiency and supplementation on plasma leptin levels in rats
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DOI：
10.1385/bter:104:1:041
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发表时间：
2005-04-01
影响因子：
3.9
通讯作者：
Halifeoglu, I
中科院分区：
文献类型：
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作者：
Baltaci, AK;Mogulkoc, R;Halifeoglu, I
本实验研究了缺锌和补锌对大鼠血浆瘦素水平的影响。缺锌饲料含锌量为0.65ppm/g的大鼠，经6周后，其平均体重显著低于正常组和补锌组，但无显著差异。血浆瘦素和锌水平在缺锌动物中最低，在接受正常饮食和每日腹膜内注射3 mg Zn/kg的动物中最高。这些结果表明，缺锌导致血浆瘦素水平的显着抑制，而补锌显着增加血浆瘦素。
The effects of zinc deficiency and supplementation on plasma leptin levels were studied in Sprague-Dawley rats. After 6 wk on a zinc-deficient diet containing 0.65 ppm Zn/g, the mean body weight was significantly lower than that of normal or zinc-supplemented rats, which showed no difference among them. The plasma leptin and zinc levels were lowest in zinc-deficient animals and highest in those that received a normal diet and daily intraperitioneal injections of 3 mg Zn/kg. These results indicate that zinc deficiency leads to a significant inhibition in plasma leptin levels, whereas zinc supplementation significantly increases plasma leptin.