Eleven years of malaria surveillance in a Sudanese village highlights unexpected variation in individual disease susceptibility and outbreak severity
Eleven years of malaria surveillance in a Sudanese village highlights unexpected variation in individual disease susceptibility and outbreak severity
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DOI：
10.1017/s0031182004005724
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发表时间：
2004-09-01
期刊：
影响因子：
2.4
通讯作者：
Arnot, DE
中科院分区：
文献类型：
--
作者：
Creasey, A;Giha, H;Arnot, DE
连续收集的数据超过11年的基础上1902 600人/天的观察Daraweesh，在苏丹东部的一个村庄的人的疟疾的经验进行了分析。疟疾传播是低流行性的：随着年龄的增长，临床免疫力的获得并不像在更全面流行的地区那样明显，在整个研究期间，疟疾在所有年龄组中仍然是一个问题。然而，这一人群，谁是富拉尼族的起源，表现出明显的疾病易感性水平的变化。32%的村民从未报告疟疾症状或需要疟疾治疗，而其他人在11年的观察中经历了8次临床发作。疟疾发病率明显受干旱影响，但受降雨影响不太明显。在多大程度上可以用按蚊因素和人类免疫因素来解释疫情模式，这仍然是疟疾建模的一个有趣问题，也是其他低传播区（如现代非洲新兴的城市地区）的一个有趣问题。
An analysis is presented of continuous data collected over 11 years based on 1902 600 person/days of observation on the malaria experience of the people of Daraweesh, a village in eastern Sudan. Malaria transmission is hypo-endemic: the acquisition of clinical immunity with age is not as obvious as in more holo-endemic areas and malaria remained a problem in all age groups throughout the study. However, this population, who are of Fulani origin, showed a distinctly variable level of disease susceptibility. Thirty-two percent of the village never reported malaria symptoms or required malaria treatment while others experienced Lip to 8 clinical episodes over the 11 years of observation. Malaria incidence was clearly influenced by drought but much less obviously by rainfall. To what extent outbreak patterns are explicable in terms of anopheline factors, and to human immune factors, remains an interesting question for malaria modelling in this, and in other low transmission zones, such as the burgeoning urban areas of modern Africa.