Dynamic Changes in Brain Activity during Prism Adaptation
Dynamic Changes in Brain Activity during Prism Adaptation
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DOI：
10.1523/jneurosci.3054-08.2009
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发表时间：
2009-01-07
影响因子：
5.3
通讯作者：
Vuilleumier, Patrik
中科院分区：
文献类型：
--
作者：
Luaute, Jacques;Schwartz, Sophie;Vuilleumier, Patrik
棱镜适应不仅诱导短期的感觉-运动可塑性，而且还能在空间的神经表征中诱导长期的重组。我们使用与事件相关的功能磁共振成像来研究视觉棱镜早期和长期暴露期间大脑活动的动态变化。参与者在棱镜曝光之前、期间和之后执行指向任务。通过逐一测试指向错误和纠正的方法，可以对大脑活动作为性能函数进行参数分析。我们发现，在棱镜暴露的最早阶段，顶前沟主要与错误检测有关，而顶枕沟与错误纠正有关。在棱镜暴露期间，小脑活动显示出进行性增加，这与空间重排的关键作用一致。这一时间进程进一步表明，小脑可能促进了在棱镜暴露后期选择性激活的颞叶上皮质的神经变化，并可能介导了棱镜适应对认知空间表征的影响。
Prism adaptation does not only induce short-term sensorimotor plasticity, but also longer-term reorganization in the neural representation of space. We used event-related fMRI to study dynamic changes in brain activity during both early and prolonged exposure to visual prisms. Participants performed a pointing task before, during, and after prism exposure. Measures of trial-by-trial pointing errors and corrections allowed parametric analyses of brain activity as a function of performance. We show that during the earliest phase of prism exposure, anterior intraparietal sulcus was primarily implicated in error detection, whereas parieto-occipital sulcus was implicated in error correction. Cerebellum activity showed progressive increases during prism exposure, in accordance with a key role for spatial realignment. This time course further suggests that the cerebellum might promote neural changes in superior temporal cortex, which was selectively activated during the later phase of prism exposure and could mediate the effects of prism adaptation on cognitive spatial representations.