Natural Agents Targeting Mitochondria in Cancer.
Natural Agents Targeting Mitochondria in Cancer.
复制标题
DOI：
10.3390/ijms21196992
复制
发表时间：
2020-09-23
影响因子：
5.6
通讯作者：
Singh KK
中科院分区：
文献类型：
--
作者：
Mani S;Swargiary G;Singh KK
线粒体是高度增殖的癌细胞的关键能量提供者，因此被认为是癌症治疗的关键靶点之一。已经研究了几种化合物在癌细胞中的线粒体靶向能力。这些研究的结果导致了“有丝分裂素”的发明，这是一种已知的精确针对癌细胞线粒体的药物。根据有丝分裂细胞的作用方式，有丝分裂细胞被分为八类。到目前为止，不同的合成化合物被认为是潜在的有丝分裂素，但不幸的是，它们被观察到会产生不利的影响。已经发表了许多研究，证明了大量天然药物的药用价值，因为它们具有线粒体靶向能力和抗癌活性，副作用最小或没有。然而，这些天然制剂从未被严格分析过其线粒体靶向活性。本综述旨在评估影响线粒体的各种自然因素，并将其归类。今后，我们的研究可能会进一步支持各种天然药物潜在的有丝分裂蛋白的行为，并强调它们在开发新的潜在抗癌治疗药物方面的意义。
Mitochondria are the key energy provider to highly proliferating cancer cells, and are subsequently considered one of the critical targets in cancer therapeutics. Several compounds have been studied for their mitochondria-targeting ability in cancer cells. These studies’ outcomes have led to the invention of “mitocans”, a category of drug known to precisely target the cancer cells’ mitochondria. Based upon their mode of action, mitocans have been divided into eight classes. To date, different synthetic compounds have been suggested to be potential mitocans, but unfortunately, they are observed to exert adverse effects. Many studies have been published justifying the medicinal significance of large numbers of natural agents for their mitochondria-targeting ability and anticancer activities with minimal or no side effects. However, these natural agents have never been critically analyzed for their mitochondria-targeting activity. This review aims to evaluate the various natural agents affecting mitochondria and categorize them in different classes. Henceforth, our study may further support the potential mitocan behavior of various natural agents and highlight their significance in formulating novel potential anticancer therapeutics.
登录
查看更多内容
影响因子：
4
作者：
Camara AKS;Zhou Y;Wen PC;Tajkhorshid E;Kwok WM
通讯作者：
Kwok WM
影响因子：
0.9
作者：
Cai, Zhen;Aguilar, Francisco X.
通讯作者：
Aguilar, Francisco X.
影响因子：
6.1
作者：
Bhujade, Arti;Gupta, G.;Patil, M. B.
通讯作者：
Patil, M. B.
影响因子：
8
作者：
Belzacq, AS;El Hamel, C;Kroemer, G
通讯作者：
Kroemer, G
影响因子：
7.4
作者：
Bhat TA;Kumar S;Chaudhary AK;Yadav N;Chandra D
通讯作者：
Chandra D