Regional cerebral blood flow in obsessive-compulsive patients with and without a chronic tic disorder.: A SPECT study.
Regional cerebral blood flow in obsessive-compulsive patients with and without a chronic tic disorder.: A SPECT study.
复制标题
DOI：
10.1007/s004060050081
复制
发表时间：
1999-06-01
影响因子：
4.7
通讯作者：
Lopez-Ibor, JJ
中科院分区：
文献类型：
--
作者：
Crespo-Facorro, B;Cabranes, JA;Lopez-Ibor, JJ
本研究的主要目的是探讨无慢性运动性抽动障碍的强迫症（OCD）患者和共病慢性抽动障碍的强迫症患者的局部脑血流量（rCBF）是否存在差异。27例强迫症患者（包括7例符合DSM-IV诊断标准的单纯慢性运动性DIC患者）和16例健康志愿者在静息状态下进行了高分辨率SPECT检查。七个感兴趣的区域（ROI）进行手动跟踪和量化的平均小脑摄取的百分比。分别采用Y-BOCS、MRS-A、HRS-D、MADRS和Yale总体捆绑严重程度量表评估强迫症状（OCS）、焦虑和抑郁症状的严重程度以及是否存在运动捆绑。我们发现，与健康志愿者相比，无运动束缚的强迫症患者右眶额皮质的rCBF显著相对降低（无运动束缚的强迫症= 0.87;健康志愿者= 0.94; p = 0.02）。直接比较有和无慢性联系的强迫症患者的rCBF无显著差异。这些结果与以前的功能性神经影像学研究相一致，这些研究广泛地涉及了强迫症的病理生理学中的眶额皮质。然而，我们的研究结果并不支持这样的想法，即强迫症患者与慢性关系可能构成一个生物亚组内的强迫症。
The main goal of the present study was to explore whether regional cerebral blood flow (rCBF) differs between obsessive-compulsive disorder (OCD) patients without chronic motor tic disorder and those OCD patients with a comorbid chronic tic disorder. Twenty-seven patients suffering from OCD (DSM-IV criteria), including 7 OCD patients who met DSM-IV criteria for simple chronic motor dic disorder, and 16 healthy volunteers were examined at rest using a high resolution SPECT. Seven regions of interest (ROIs) were manually traced and quantified as a percentage of the mean cerebellar uptake. Severity of obsessive-compulsive symptoms (OCS), anxiety and depressive symptoms and presence of motor ties were assessed with the Y-BOCS, MRS-A, HRS-D, MADRS, and Yale Global Ties Severity Scale, respectively. We found a significant relative decrease in rCBF in OCD patients without motor ties compared to healthy volunteers in the right orbitofrontal cortex (OCD without ties = 0.87; healthy volunteers = 0.94; p = 0.02). No significant differences in rCBF were seen when OCD patients with and without chronic ties were directly compared. A lower severity of OCS in OCD patients with chronic ties was found. These results are consistent with previous functional neuroimaging studies at rest that have widely involved the orbitofrontal cortex in the pathophysiology of the OCD. However, our results do not support the idea that OCD patients with chronic ties may constitute a biological subgroup within the OCD.