Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential
Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential
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DOI：
10.1111/j.0303-6987.2005.00282.x
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发表时间：
2005-02-01
影响因子：
1.7
通讯作者：
Seykora, JT
中科院分区：
文献类型：
--
作者：
Wu, H;Barusevicius, A;Seykora, JT
背景：黑色素瘤和黑色素瘤组织的基因表达谱显示，多营养素(PTN)在人类黑色素瘤中显著过表达。方法：为了进一步评估PTN在黑素细胞病变中的表达，对黑素细胞病变进行了蛋白质免疫组织化学染色。结果：黑色素细胞痣始终为阴性(n=58)。而转移性黑色素瘤绝大多数为阳性(33/34，97%)。对34例原发性黑色素瘤的分析显示，20个病灶中PTN阳性，14个病灶为阴性。在原发黑色素瘤中，PTN免疫反应与转移(p=0.0004)和降低黑色素瘤相关生存期(p=0.0444)相关。PTN免疫反应的单变量分析预测转移风险增加(相对危险度9.1，p=0.003)。结论：本研究结果证实了先前的基因图谱数据，表明PTN在黑色素细胞痣和黑色素瘤中的表达存在差异。此外，皮损中PTN的表达与转移潜能有关，可能是黑色素瘤的预后因素。
Background: Gene expression profiling of melanoma and nevic tissue has demonstrated that pleiotrophin (PTN) is significantly overexpressed in human melanomas.Methods: To further evaluate PTN expression in melanocytic lesions, protein immunohistochemistry was performed on the spectrum of melanocytic lesions.Results: Melanocytic nevi were consistently negative (n = 58). In contrast, the great majority of metastatic melanomas were positive (33/34, 97%). The analysis of 34 primary melanomas demonstrated PTN positivity in 20 lesions while 14 lesions were negative. Within the primary melanomas, PTN immunoreactivity was associated with metastasis (p = 0.0004) and decreased melanoma-related survival (p = 0.0444). Univariate analysis of PTN immunoreactivity predicted an increased risk for metastasis (relative risk 9.1, p = 0.003).Conclusions: The results of this study confirm previous gene profiling data showing differential PTN expression between melanocytic nevi and melanomas. In addition, lesional PTN expression is associated with metastatic potential and may be a prognostic factor for melanomas.