Intravenous Midazolam Suppresses Noxiously Evoked Activity of Spinal Wide Dynamic Range Neurons in Cats
Intravenous Midazolam Suppresses Noxiously Evoked Activity of Spinal Wide Dynamic Range Neurons in Cats
复制标题
静脉注射咪达唑仑抑制猫脊髓宽动态范围神经元的有害诱发活动
作者：
T. Sumida;M. Tagami;Y. Ide;M. Nagase;H. Sekiyama;K. Hanaoka
在去大脑、脊髓横断的猫中，研究了静脉（IV）给予咪达唑仑对脊髓宽动态范围（WDR）神经元的毒性诱发活动的影响。在刺激期间通过捏住后爪上的感受野测量细胞外单单位记录，并测量咪达唑仑在0.25、0.5、1、2和4 mg/kg剂量下的作用。进行了两个系列的实验来表征咪达唑仑的镇痛作用。在第一，剂量反应实验（n = 59）证明了剂量依赖性抑制脊髓WDR神经元的毒性诱发活动后咪达唑仑管理。咪达唑仑的这种作用在1 mg/kg IV剂量下最大。第二组实验（n = 14）表明，苯二氮卓类拮抗剂氟马西尼（n = 8）可迅速逆转咪达唑仑的作用，而阿片类拮抗剂纳洛酮（n = 6）对咪达唑仑的作用无影响。目前的研究表明，静脉注射咪达唑仑抑制脊髓WDR神经元的毒性诱发活动，这是可逆的苯二氮卓类拮抗剂。这与咪达唑仑的镇痛作用一致。（Anesth Analg 1995;80：58-63）
The effects of intravenously (IV) administered midazolam on noxiously evoked activity of spinal wide dynamic range (WDR) neurons were investigated in decerebrate, spinal-cord-transected cats. Extracellular, single-unit recordings were measured during stimulation by pinching the receptive field on the hind paw and the effect of midazolam at doses of 0.25, 0.5, 1, 2, and 4 mg/kg were measured. Two series of experiments were performed to characterize the analgesic effects of midazolam. In the first, dose-response experiments (n = 59) demonstrated a dose-dependent suppression of the noxiously evoked activity of spinal WDR neurons after midazolam administration. This effect of midazolam was maximal at a dose of 1 mg/kg IV. The second series of experiments (n = 14) demonstrated that a benzodiazepine antagonist, flumazenil (n = 8), promptly reversed the effect of midazolam, while an opioid antagonist, naloxone (n = 6), had no effect on the effect of midazolam. The present study demonstrates that IV administered midazolam suppresses noxiously evoked activity of spinal WDR neurons that is reversible by a benzodiazepine antagonist. This is consistent with an analgesic action of midazolam. (Anesth Analg 1995;80:58-63)
吗啡镇痛与纳洛酮敏感和西咪替丁敏感应激镇痛之间的交叉耐受性和交叉敏化。
DOI：
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发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
Weinstein,IJ;Hough,LB;Gogas,KR
通讯作者：
Gogas,KR