Benefits of improved air quality on ageing lungs: impacts of genetics and obesity
Benefits of improved air quality on ageing lungs: impacts of genetics and obesity
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DOI：
10.1183/13993003.01780-2018
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发表时间：
2019-04-01
影响因子：
24.3
通讯作者：
Schikowski, Tamara
中科院分区：
文献类型：
--
作者：
Huels, Anke;Sugiri, Dorothee;Schikowski, Tamara
引言：改善空气质量对老年人肺功能的有益影响尚不清楚。我们研究了空气污染物和肺功能的下降之间的关联，并通过遗传学和身体质量指数（BMI）的影响修改，在老年德国women.Methods：数据进行了分析，从前瞻性的SALIA（研究空气污染对肺功能的影响，炎症和衰老）研究（n= 601）。在基线（1985-1994年;年龄55岁）、2007-2010年和2012-2013年进行肺量测定。使用土地使用回归模型确定每个时间点家庭住址的空气污染浓度。计算全球肺脏倡议2012年z评分。根据肺功能相关风险等位基因确定加权遗传风险评分（GRS），并用于研究与改善空气质量的相互作用。多元线性混合模型拟合。结果：空气污染水平大幅下降，在研究期间。空气污染的减少与1秒用力呼气量（FEV 1）和FEV 1/用力肺活量比的z分数增加有关。二氧化氮（NO2）浓度每减少10 μ g.m（-3），FEV 1的z分数增加0.14（95%CI 0.01-0.26）。然而，随着肺功能相关风险等位基因数量的增加，改善空气质量的益处减少（GRSxNO（2）相互作用：p=0.029）。与BMI的相互作用不显着。结论：减少空气污染与老年妇女肺功能的相对改善有关，但也取决于他们的遗传组成。
Introduction: The beneficial effect of improving air quality on lung function in the elderly remains unclear. We examined associations between decline in air pollutants and lung function, and effect modifications by genetics and body mass index (BMI), in elderly German women.Methods: Data were analysed from the prospective SALIA (Study on the influence of Air pollution on Lung function, Inflammation and Aging) study (n= 601). Spirometry was conducted at baseline (1985-1994; age 55 years), in 2007-2010 and in 2012-2013. Air pollution concentrations at home addresses were determined for each time-point using land-use regression models. Global Lung Initiative 2012 z-scores were calculated. Weighted genetic risk scores (GRSs) were determined from lung function-related risk alleles and used to investigate interactions with improved air quality. Multiple linear mixed models were fitted.Results: Air pollution levels decreased substantially during the study period. Reduction of air pollution was associated with an increase in z-scores for forced expiratory volume in 1 s (FEV1) and the FEV1/forced vital capacity ratio. For a decrease of 10 mu g.m(-3) in nitrogen dioxide (NO2), the z-score for FEV1 increased by 0.14 (95% CI 0.01-0.26). However, with an increasing number of lung function-related risk alleles, the benefit from improved air quality decreased (GRSxNO(2) interaction: p=0.029). Interactions with BMI were not significant.Conclusions: Reduction of air pollution is associated with a relative improvement of lung function in elderly women, but also depends on their genetic make-up.