Retinal ganglion cell axons regenerate in the presence of intact sensory fibres.
Retinal ganglion cell axons regenerate in the presence of intact sensory fibres.
复制标题
视网膜神经节细胞轴突在完整感觉纤维存在的情况下再生。
DOI：
10.1097/01.wnr.0000195668.07467.a8
复制
发表时间：
2006
期刊：
影响因子：
1.7
通讯作者：
Beazley,Lyn
中科院分区：
文献类型：
--
作者：
King,Carolyn;Bartlett,Carole;Sauvé,Yves;Lund,Ray;Dunlop,Sarah;Beazley,Lyn
一种新的同种异体移植模式被用来测试成年哺乳动物中央轴突是否在周围神经环境中再生，周围神经环境中包含完整的感觉轴突。比较了大鼠视神经与背根神经节移植吻合后视网膜神经节细胞轴突的再生情况。背根神经节移植物包括完整的感觉轴突和退化的运动轴突，而传统移植物包括退化的感觉轴突和运动轴突。2个月后追踪视网膜神经节细胞轴突。背根神经节存活，其轴突在整个移植过程中持续存在。视网膜神经节细胞向背根神经节再生轴突的数量（1053±223）与常规移植（1323±881;P < 0.05）相当。结果表明，完整的感觉环境支持中枢轴突再生。
A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adult rat optic nerve. Dorsal root ganglia grafts comprised intact sensory and degenerate motor axons, whereas conventional grafts comprised both degenerating sensory and motor axons. Retinal ganglion cell axons were traced after 2 months. Dorsal root ganglia survived with their axons persisting throughout the graft. Comparable numbers of retinal ganglion cells regenerated axons into both dorsal root ganglia (1053±223) and conventional grafts (1323±881; P> 0.05). The results indicate that an intact sensory environment supports central axon regeneration.