INTRA-AORTIC BALLOON COUNTERPULSATION IN CARDIOGENIC-SHOCK - REPORT OF A COOPERATIVE CLINICAL TRIAL
INTRA-AORTIC BALLOON COUNTERPULSATION IN CARDIOGENIC-SHOCK - REPORT OF A COOPERATIVE CLINICAL TRIAL
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DOI：
10.1056/nejm197305102881901
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发表时间：
1973-01-01
影响因子：
158.5
通讯作者：
KANTROWITZ, A
中科院分区：
文献类型：
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作者：
SCHEIDT, S;WILNER, G;KANTROWITZ, A
87例心源性休克患者在10个机构根据共同协议接受主动脉内反搏球囊治疗。大多数患者的临床和生理反应良好。心率从110 ± 24（平均值± S.D.）至103 ± 21次/分钟，动脉收缩压（“后负荷”）从76 ± 22降至57 ± 17 mm Hg，动脉舒张压从53 ± 12增至83 ± 19 mm Hg，平均动脉压不变。心输出量每分钟增加500 ml，19例代谢研究患者中有18例发生心肌乳酸产生减少或乳酸提取增加。52名患者在球囊辅助期间死亡，35名幸存者;其中15名幸存者离开医院，8名存活超过一年。试图提前预测生存率，或根据对球囊反搏的反应，通常是不成功的，球囊反搏的启动和终止的精确指征仍然存在疑问。（《新英格兰医学杂志》288：979-984，1973）
Eighty-seven patients with cardiogenic shock were treated with the intra-aortic counterpulsating balloon in 10 institutions according to a common protocol. Clinical and physiologic responses were favorable in most patients. Heart rate fell from 110 ± 24 (mean ± S.D.) to 103 ± 21 beats per minute, systolic arterial pressure ("afterload") fell from 76 ± 22 to 57 ± 17 mm Hg, diastolic arterial pressure increased from 53 ± 12 to 83 ± 19 mm Hg, and mean arterial pressure did not change. Cardiac output increased 500 ml per minute, and a decrease in lactate production or increase in lactate extraction by the myocardium occurred in 18 of 19 patients with metabolic studies. Fifty-two patients died during balloon assistance, and 35 survived; 15 of the survivors left the hospital, and eight have lived for more than one year. Attempts to predict survival in advance, or from response to balloon counterpulsation, were generally unsuccessful, and precise indications for initiation and termination of balloon counterpulsation remain in doubt. (N Engl J Med 288:979–984, 1973)