HEPATIC-ARTERY INFUSION AND CHEMOEMBOLIZATION IN THE MANAGEMENT OF LIVER METASTASES
HEPATIC-ARTERY INFUSION AND CHEMOEMBOLIZATION IN THE MANAGEMENT OF LIVER METASTASES
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DOI：
10.1007/bf02575467
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发表时间：
1990-06-01
影响因子：
2.9
通讯作者：
GIANTURCO, C
中科院分区：
文献类型：
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作者：
WALLACE, S;CARRASCO, CH;GIANTURCO, C
肝转移瘤而不是原发肿瘤通常决定了疾病的进程和患者的生存。对于不可切除的疾病，动脉灌注化疗、栓塞和化疗栓塞是可行的替代方案。肝转移瘤的动脉内治疗是基于正常肝脏（门静脉，75%，肝动脉，25%）和肿瘤（肝动脉，90%）的双重血液供应。动脉内灌注可提供更高浓度的化疗，而化疗栓塞会增加局部缺血并增加与肿瘤的接触时间。用于输注的选择性血管闭塞、血液供应的重新分布和脉动流增强了治疗剂向肝脏的递送。
Hepatic metastases rather than the primary neoplasm usually dictate the course of the disease and the patient's survival. For unresectable disease, intraarterial infusion of chemotherapy, embolization, and chemoembolization are viable alternatives. Intraarterial therapy for hepatic metastases is based on the dual blood supply of the normal liver (portal vein, 75%, and hepatic artery, 25%) and that of the tumors (hepatic artery, 90%). Intraarterial infusion delivers a higher concentration of chemotherapy, whereas chemoembolization adds ischemia and increased contact time with the tumor. Selective vascular occlusion for infusion, redistribution of the blood supply and pulsatile flow enhance the delivery of therapeutic agents to the liver.