DESMOSOMAL PROTEINS - MEDIATORS OF INTERCELLULAR COUPLING AND INTERMEDIATE FILAMENT ANCHORAGE
DESMOSOMAL PROTEINS - MEDIATORS OF INTERCELLULAR COUPLING AND INTERMEDIATE FILAMENT ANCHORAGE
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DOI：
10.1101/sqb.1992.057.01.070
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
LEUBE, RE
中科院分区：
文献类型：
--
作者：
FRANKE, WW;TROYANOVSKY, SM;LEUBE, RE
细胞内和细胞间结构的建立和维持涉及稳定的细胞接触结构（“连接”），其表现为不同的质膜结构域，其特征在于相邻细胞的表面膜的紧密并置和任一细胞质侧上的致密层（“斑块”）。这些斑块反过来又可以作为锚定板，用于特定种类的细胞骨架丝的缔合。两种主要类型的这种带有噬斑的细胞间连接（“粘附连接”）可以通过形态学（Farquhar和Palade 1963）和生物化学标准（Franke et al. 1982;盖革et al. 1983，1985; Cowin et al. 1985 b，1986）来区分：桥粒（maculae adhaerentes）直径大多为0.1-0.5 μ m，参与中等大小纤维（IF）的锚定和上皮细胞、心肌细胞和脑膜细胞以及淋巴结滤泡的树突状网状细胞的细胞间偶联--并因此参与组织形成。在上皮细胞中，这些斑块通常与细胞角蛋白类的IF相关（综述见Moll et al. 1982; Steinert and Roop 1988），而心肌和心脏浦肯野纤维细胞的桥粒斑块与含结蛋白的IF相关，某些脑膜和树突网状细胞的桥粒斑块与波形蛋白IF相关（Cowin et al. 1985 b; Moll et al. 1986）。
The establishment and maintenance of intra-and intercellular architecture involves stable cell contact structures (" junctions") that appear as distinct plasma membrane domains characterized by close apposition of the surface membranes of neighboring cells and a dense layer (" plaque") on either cytoplasmic side. These plaques in turn can serve as anchoring plates for the association of specific kinds of cytoskeletal filaments. Two major kinds of such plaque-bearing intercellular junctions (" adhering junctions") can be distinguished by morphological (Farquhar and Palade 1963) and biochemical criteria (Franke et al. 1982; Geiger et al. 1983, 1985; Cowin et al. 1985b, 1986):1. Desmosomes (maculae adhaerentes), mostly 0.1-0.5/~ m in diameter, are involved in the anchorage of intermediate-sized filaments (IFs) and in the intercellular coupling--and hence tissue formation--of epithelial cells, but also of myocardial and meningeal cells and the cells of the dendritic reticulum of lymph node follicles. In epithelia, these plaques are usually associated with IFs of the cytokeratin category (for reviews, see Moll et al. 1982; Steinert and Roop 1988), whereas desmosomal plaques of myocardiac and Purkinje fiber cells of the heart are associated with desmin-containing IFs and those of certain meningeal and of dendritic reticulum cells with vimentin IFs (Cowin et al. 1985b; Moll et al. 1986).