Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.
Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.
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通过可溶性小球疫苗预防致命的鼠球孢子菌病。
DOI：
10.1128/iai.66.5.2342-2345.1998
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发表时间：
1998
影响因子：
3.1
通讯作者：
Pappagianis,D
中科院分区：
文献类型：
--
作者：
Zimmermann,CR;Johnson,SM;Martens,GW;White,AG;Zimmer,BL;Pappagianis,D
甲醛灭活的全球疫苗可防止实验室动物遭受粗球孢子菌的致命攻击，并进行了分级。它产生了一种可溶性、多组分、亚细胞部分，称为 27K 疫苗。当这种疫苗与佐剂一起使用时，可以保护小鼠免受致命的鼻内和静脉注射艰难梭菌的攻击。免疫炎。
The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals withCoccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge withC. immitis.