Lack of replication of a previously reported association between polymorphism in the 3′UTR of the alpha-synuclein gene and Parkinson's disease in Chinese subjects
Lack of replication of a previously reported association between polymorphism in the 3′UTR of the alpha-synuclein gene and Parkinson's disease in Chinese subjects
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DOI：
10.1016/j.neulet.2010.05.022
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发表时间：
2010-07-19
影响因子：
2.5
通讯作者：
Xu, Y-M
中科院分区：
文献类型：
--
作者：
Hu, F-Y;Hu, W-B;Xu, Y-M
最近的研究表明，α-突触核蛋白（SNCA）基因3'非翻译区（3' UTR）的多态性与帕金森病（PD）的发生有关。单核苷酸多态性（single nucleotide polymorphism，SNP）rs356165是位于3 'UTR的多态性之一，其与帕金森病的相关性已有报道，但仍存在争议。因此，我们进行了一项病例对照研究，以进一步评估SNP rs356165与中国人PD的可能关联。所有受试者（330例PD患者和300名正常对照）成功地使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析基因型。病例组和对照组之间的基因型频率无统计学显著差异（P=0.863），表明SNP rs356165与我们人群中的PD无关。因此，这可能是过早的SNCA基因的3 'UTR和PD之间的关联，这种关联应在不同的种族人群中进一步检查。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Recent studies have implicated polymorphisms in the 3' untranslated region (3'UTR) of the alpha-synuclein (SNCA) gene in the development of Parkinson's disease (PD). Single nucleotide polymorphism (SNP) rs356165 is one of polymorphisms located in the 3'UTR and its association with PD has been reported but remains controversial. Herein, we conducted a case-control study to further evaluate the possible association between SNP rs356165 and PD in Chinese. All subjects (330 PD patients and 300 normal controls) were successfully genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. No statistically significant difference in genotype frequency between cases and controls was observed (P=0.863), suggesting no association of SNP rs356165 with PD in our population. Thus, it may be premature to conclude an association between the 3'UTR of the SNCA gene and PD, and this association should be further examined in different ethnic populations. (C) 2010 Elsevier Ireland Ltd. All rights reserved.