Utilization of Iron from an Animal-Based Iron Source Is Greater Than That of Ferrous Sulfate in Pregnant and Nonpregnant Women
Utilization of Iron from an Animal-Based Iron Source Is Greater Than That of Ferrous Sulfate in Pregnant and Nonpregnant Women
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DOI：
10.3945/jn.110.127209
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发表时间：
2010-12-01
影响因子：
4.2
通讯作者：
O'Brien, Kimberly O.
中科院分区：
文献类型：
--
作者：
Young, Melissa F.;Griffin, Ian;O'Brien, Kimberly O.
妊娠期间血红素铁的吸收和铁调素在调节膳食血红素铁吸收中的作用在很大程度上尚未探索。本研究的目的是检查妊娠期间血红素铁吸收的相对差异。（动物）和非血红素（硫酸亚铁）铁的利用（年龄16-32岁，妊娠32-35周）和11名非妊娠女性（年龄18-27岁）妇女被随机分配接受动物血红素餐，（内在标记的Fe-58猪肉）和标记的硫酸亚铁（Fe-57）隔日进食给药后2周获得的血样用于评估铁状态指标和血清铁调素以及基于RBC的铁利用铁同位素掺入：妊娠妇女（147 7 ± 144）和非妊娠妇女（404 ± 13 2%）的血红素铁利用率显著高于非血红素铁利用率（50 1 +/- 148 vs 153 9 +/- 7%）通过血清转铁蛋白受体浓度评估，孕妇对非血红素铁的利用与铁状况相关（P = 0 0 0 3 r（2）= 0 431）而血红素铁的利用率不受母体铁状况的影响。在整个组中，血清铁调素检测不到的妇女比血清铁调素检测到的妇女有更高的非血红素铁利用率（P = 0.02 n = 29）而血红素铁利用率无显著差异。为孕妇和非孕妇提供了高生物利用度的膳食铁来源，与硫酸亚铁相比，铁调素浓度或铁储存量不敏感J Nutr 140 2162-2166 2010
Heme iron absorption during pregnancy and the role of hepcidin in regulating dietary heme iron absorption remains largely unexplored The objective of this research was to examine relative differences in heme (animal based) and nonheme (ferrous sulfate) iron utilization This study was undertaken in 18 pregnant (ages 16-32 y wk 32-35 of gestation) and 11 nonpregnant women (ages 18-27 y) Women were randomly assigned to receive both an animal based heme meal (intrinsically labeled Fe-58 pork) and labeled ferrous sulfate (Fe-57) fed on alternate days Blood samples obtained 2 wk postdosing were used to assess iron status indicators and serum hepcidin and iron utilization based on R BC incorporation of iron isotopes Heme iron utilization was significantly greater than nonheme iron utilization in the pregnant 147 7 +/- 144 vs 404 +/- 13 2%) and nonpregnant women (50 1 +/- 148 vs 153 9 +/- 7%) Among pregnant women utilization of nonheme iron was associated with iron status as assessed by the serum transferrin receptor concentration (P = 0 003 r(2) = 0 431 In contrast heme iron utilization was not influenced by maternal iron status In the group as a whole women with undetectable serum hepcidin had greater nonheme iron utilization compared with women with detectable serum hepcidin (P = 0 02 n = 29) however there were no significant differences in heme iron utilization Our study suggests that iron utilization from an animal-based food provides a highly bioavailable source of dietary iron for pregnant and nonpregnant women that is not as sensitive to hepcidin concentrations or iron stores compared with ferrous sulfate J Nutr 140 2162-2166 2010