Relationship of growth and blood pressure in inbred rats.
Relationship of growth and blood pressure in inbred rats.
复制标题
近交系大鼠生长与血压的关系。
DOI：
10.1152/ajpregu.1994.266.3.r702
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Weder,AB
中科院分区：
文献类型：
--
作者：
Schork,NJ;Jokelainen,P;Grant,EJ;Schork,MA;Weder,AB
血压和体重随着年龄的增长而上升，高血压被认为是早期生长障碍的结果。我们使用样条拟合的统计技术来检查Wistar-Kyoto、自发性高血压（SHR）和卒中易发SHR品系的个体近交系大鼠的生长和血压升高的模式。我们的结果表明，生长是阶段性的，每个菌株在大约50日龄时都有一个明确的生长高峰。此外，体重最大增加的时间与血压骤升的开始时间相对应。这一血压上升的时间在三个品系中相似，但高血压品系的最大血压上升率明显更高。我们的研究结果表明，生长和血压升高密切相关。血压似乎随着生长突增而升高，这表明有一些与生长有关的事件触发了心血管反应。
Blood pressure and body weight rise with age, and hypertension is hypothesized to result from an early disorder of growth. We used the statistical technique of spline fitting to examine patterns of growth and rising blood pressure in individual inbred rats of the Wistar-Kyoto, spontaneously hypertensive (SHR), and stroke-prone SHR strains. Our results indicate that growth is phasic and that a well-defined growth spurt peaks at approximately 50 days of age in each strain. In addition, the time of maximal weight gain corresponds to the onset of a blood pressure spurt. The timing of this blood pressure rise was similar in the three strains, but the maximal rate of blood pressure rise was significantly higher in the hypertensive strains. Our results suggest that growth and rising blood pressure are intimately linked. Blood pressure appears to rise in response to a growth spurt, suggesting that there are growth-related events that trigger the cardiovascular response.