Structural and Stereochemical Studies of Laurokamurols A-C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada
Structural and Stereochemical Studies of Laurokamurols A-C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada
复制标题
中国红藻中罕见的双倍半萜类月桂醇 A-C 的结构和立体化学研究 Laurencia okamurai Yamada
DOI：
10.1021/acs.jafc.6b05238
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发表时间：
2017-03-01
影响因子：
6.1
通讯作者：
Guo, Yue-Wei
中科院分区：
文献类型：
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作者：
Li, Xiao-Lu;Kurtan, Tibor;Guo, Yue-Wei
从东海红藻凹顶藻（Laurencia okamurai Yamada）中分离得到3个新的异二聚体月桂烷型倍半萜类化合物laurokamurols A-C（1-3）沿着8个已知的单体化合物laurokamurols A-C（4-11）。通过大量的光谱分析和TDDFT-ECD方法，确定了新的双倍半萜类化合物的绝对构型，特别是它们的轴向手性。所有新化合物都显示出有希望的PTP 1B抑制活性，其IC 50值与阳性对照相当，表明它们是潜在的食品添加剂或导致肥胖或糖尿病的药物。
Three novel heterodimeric laurane-type sesquiterpenoids, laurokamurols A-C (1-3), along with eight known related monomeric ones (4-11) were isolated from the East China Sea red alga Laurencia okamurai Yamada. The absolute configurations of the new bis-sesquitepenoids, especially their axial chirality, were determined by extensive spectroscopic analyses and TDDFT-ECD method. All of the new compounds showed promising PTP1B inhibitory activities with IC50 values comparable to the positive control, indicating them as potential food additives or pharmaceutical drug leads toward obesity or diabetes.