Visceral pain in humans: lessons from animals.
Visceral pain in humans: lessons from animals.
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DOI：
10.1007/s11916-001-0009-y
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发表时间：
2001-02-01
影响因子：
3.7
通讯作者：
Buffington, C A
中科院分区：
文献类型：
--
作者：
Buffington, C A
健康动物的急性和持续性神经病理性和炎症性损伤对我们目前对伤害感受和疼痛的理解做出了重要贡献。研究将躯体伤害性输入与内脏伤害性输入区分开来，并阐明了输入的转导、传递、感知和调节途径。其他动物研究已经确定了遗传和环境对伤害感受反应的重要影响。对动物自然发生的内脏疼痛综合症的研究也增加了我们对人类类似综合症的理解。由于疼痛具有令人厌恶的性质，使用健康的动物来研究疼痛以服务其他动物和人类是一个需要谨慎做出的决定，并承担着尽可能人道地对待动物的责任。
Acute and persistent neuropathic and inflammatory injuries of healthy animals have contributed importantly to our current understanding of nociception and pain. Studies have differentiated somatic from visceral nociceptive input, and elucidated the pathways of transduction, transmission, perception, and modulation of the input. Other animal studies have identified important genetic and environmental influences on responses to nociception. Studies of naturally occurring visceral pain syndromes in animals also have added to our understanding of comparable syndromes in humans. Because of the aversive nature of pain, use of healthy animals to study pain in the service of other animals and humans is a decision to be taken carefully, and carries with it the responsibility of treating the animals as humanely as possible.