Uterine artery hemodynamic adaptations through the menstrual cycle into early pregnancy
Uterine artery hemodynamic adaptations through the menstrual cycle into early pregnancy
复制标题
DOI：
10.1016/s0029-7844(01)01787-2
复制
发表时间：
2002-04-01
影响因子：
7.2
通讯作者：
Badger, GJ
中科院分区：
文献类型：
--
作者：
Bernstein, IM;Ziegler, WF;Badger, GJ
目的：评价人子宫动脉血管从月经周期进入妊娠早期的适应过程。方法：我们前瞻性地测量了怀孕妇女在月经周期和妊娠4、6、12周时的子宫动脉搏动指数、峰值收缩速度和容量血流量。上肢桡动脉作为对照血管进行血流动力学检查。10名受试者在12个月内怀孕进行月经周期研究。分析采用重复测量方差分析，P < 0.05为显著性。结果：在怀孕妇女中，子宫动脉收缩速度在观察期间显著增加，从月经周期第10天开始（0.36 × 0.02 m / s），持续到12周（1.05 +/- 0.10 m / s, P < .001）。观察窗内子宫动脉搏动指数由卵泡期的3.0 +/- 0.2降至月经12周时的1.6 +/- 0.2 （P < 0.001）。子宫动脉血流量从月经周期第10天（22.2 +/- 1.8 mL / min）到妊娠12周（150.2 +/- 40.3 mL / min, P < 0.001）显著增加。这些模式与桡动脉观察到的模式明显不同。结论：妊娠早期子宫动脉血流动力学适应遵循月经周期中建立的连续体。这些适应导致子宫动脉阻抗降低和血流量增加。这些变化不同于在上肢桡动脉（控制血管）中观察到的变化，提示局部盆腔和全身血流动力学适应的独立性。（妇产科，2002;99:620-24）(C) 2002年由美国妇产科医师学会发布。
OBJECTIVE: To estimate the time course of human uterine artery vascular adaptation through the menstrual cycle into early pregnancy.METHODS: We prospectively measured the uterine artery pulsatility index, peak systolic velocity, and volumetric blood flow during the menstrual cycle and at 4, 6, and 12 weeks of pregnancy in women who conceived. Upper extremity radial artery hemodynamic changes were examined as a control vessel. Ten subjects conceived within 12 months of menstrual cycle studies. Analyses were performed using repeated measures analysis of variance with P < .05 accepted for significance.RESULTS: In women who conceived, uterine artery peals systolic velocity demonstrated a significant increase during the period of observation, which began after cycle day 10 (0.36 x 0.02 meters per second) of the menstrual cycle and continued though 12 menstrual weeks (1.05 +/- 0.10 meters per second, P < .001). Uterine artery pulsatility index decreased significantly during the observation window from 3.0 +/- 0.2 in the follicular phase to 1.6 +/- 0.2 at 12 menstrual weeks (P < .001). Blood flow in the uterine artery increased significantly from cycle day 10 (22.2 +/- 1.8 mL per minute) to 12 menstrual weeks' gestation (150.2 +/- 40.3 mL per minute, P < .001). These patterns were significantly different from the patterns observed for the radial artery.CONCLUSION: Uterine artery hemodynamic adaptation in early pregnancy follows a continuum established during the menstrual cycle. These adaptations result in decreased uterine artery impedance and increased blood flow. These changes differ from those observed in the upper extremity radial artery (control vessel) suggesting independence of regional pelvic and systemic hemodynamic adaptations. (Obstet Gynecol 2002;99:620-24. (C) 2002 by the American College of Obstetricians and Gynecologists.).