RESPIRATORY-ASSOCIATED THALAMIC ACTIVITY IS RELATED TO LEVEL OF RESPIRATORY DRIVE
RESPIRATORY-ASSOCIATED THALAMIC ACTIVITY IS RELATED TO LEVEL OF RESPIRATORY DRIVE
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DOI：
10.1016/0034-5687(92)90137-l
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发表时间：
1992-10-01
期刊：
影响因子：
--
通讯作者：
WAGNER, PG
中科院分区：
文献类型：
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作者：
CHEN, ZB;ELDRIDGE, FL;WAGNER, PG
我们记录了未麻醉、颞上失觉、麻痹和通气猫的膈神经活动和丘脑单单元放电，其中迷走神经和颈动脉窦神经（CSN）已被切除。在丘脑上行网状系统相关区域的545个神经元中，有76个（14%）神经元在低呼吸驱动时呈紧张性放电，当CSN刺激或高碳酸盐增加呼吸驱动时，每次呼吸都会出现节律性放电增加。神经元放电增加发生在吸气后期/吸气后，但有时持续到呼气；变化的大小根据呼吸活动的大小进行分级。丘脑神经元也以与呼吸机诱导的胸部扩张相关的节奏放电，一些单位同时显示呼吸相关和呼吸机相关的节奏。同时记录的中脑和丘脑神经元在驱动力增强时也出现了类似的节律。我们认为，这些神经元活动反映了呼吸信息向皮层的传递，这可能导致呼吸困难的感觉，也可能导致觉醒。
We recorded phrenic nerve activity and thalamic single unit firing in unanesthetized, suprathalamically decerebrated, paralyzed and ventilated cats, in which vagi and carotid sinus nerves (CSN) had been ablated. Seventy-six (14%) of 545 neurons in regions of the thalamus related to the ascending reticular system, which had been tonically firing at low respiratory drives, developed rhythmic increases of firing associated with each respiration when drive had been increased by CSN stimulation or hypercapnia. The increases of neuronal firing occurred in late inspiration/post-inspiration but sometimes lasted into expiration; the magnitude of change was graded according to the magnitude of respiratory activity. Thalamic neurons also fired with a rhythm related to ventilator-induced chest expansion, some units showing both the respiratory-associated and the ventilator-related rhythms. Simultaneously recorded mesencephalic and thalamic neurons developed similar rhythms when drive was increased. We suggest that these neuronal activities reflect the conveyance of information about respiration to the cortex, where it may lead to the sensation of dyspnea and perhaps to arousal.