Image analysis framework with focus evaluation for in situ characterisation of particle size and shape attributes
Image analysis framework with focus evaluation for in situ characterisation of particle size and shape attributes
复制标题
DOI：
10.1016/j.ces.2018.06.067
复制
发表时间：
2018-12-14
影响因子：
4.7
通讯作者：
Tachtatzis, Christos
中科院分区：
文献类型：
--
作者：
Cardona, Javier;Ferreira, Carla;Tachtatzis, Christos
颗粒加工行业，如制药、食品加工和消费品行业，越来越需要控制和设计颗粒属性的策略。在传统的间歇和连续工艺中，需要通过Process Analytical Technologies的在线测量来有效地监控颗粒尺寸和形状。然而，从这些测量中获得定量信息已被证明是具有挑战性的，并且在线成像技术主要用于定性目的。两个关键的挑战是：（1）焦点外物体的存在和（2）图像仅表示三维物体的2D投影。在这项工作中，一种新的框架，以处理帧从在线成像探头结合了一个焦点评估步骤，以提取有意义的定量形状和大小的信息，通过拒绝的焦点外的颗粒。此外，提出了一个模型，模拟的三维颗粒的焦平面上的2D投影，并计算相应的大小和形状分布。该框架是量化的，并评估对标准颗粒的明确定义的大小和形状，如聚苯乙烯微球和针状立方体硅颗粒。(C)2018作者爱思唯尔有限公司出版
Particle processing industries, such as pharmaceutical, food processing and consumer goods sectors, increasingly require strategies to control and engineer particle attributes. In both traditional batch and continuous processes, particle size and shape need to be effectively monitored through in-line measurements from Process Analytical Technologies. However, obtaining quantitative information from these measurements has proven to be challenging and in-line imaging techniques are primarily used for qualitative purposes. Two key challenges are: (1) the presence of out-of-focus objects and (2) images only represent 2D projections of three-dimensional objects. In this work, a novel framework to process frames from in-line imaging probes incorporates a focus evaluation step in order to extract meaningful quantitative shape and size information through rejection of out-of-focus particles. Furthermore, a model is proposed that simulates the 2D projection of three-dimensional particles onto the focal plane and computes the corresponding size and shape distributions. The framework is quantified and evaluated against standard particles of well-defined size and shape such as polystyrene microspheres and needle-like cuboid silicon particles. (C) 2018 The Authors. Published by Elsevier Ltd.